Scientist, Biologics Purification

AbbVie Inc.; Chicago (IL); Hybrid; USD 90,000 - 130,000; Full time

Job summary

AbbVie’s Biologics Discovery Sciences group seeks a scientist focused on Biologics Purification to advance innovative biologic therapies. You will lead purification campaigns to deliver high-purity multi-specific antibody biologics for in vitro and in vivo studies.

The role requires expertise in preparative-scale chromatography (AKTA, IEX, HIC), strong analytical skills (HPLC, ELISA, MS), and collaboration across teams to translate insights into project decisions.

Qualifications

• BS or MS in Biochemistry, Biophysics, Biomedical, Chemical Engineering required.
• Experience with preparative-scale column chromatography for antibody biologics.
• Hands-on AKTA chromatography systems and Unicorn software.
• Strong analytical characterization skills (HPLC, GE, ELISA, MS).
• Understanding of biologics manufacturing or process development is a plus.

Responsibilities

• Lead end-to-end purification campaigns at production-scale.
• Design and optimize downstream purification strategies using chromatography.
• Characterize molecules, process intermediates, impurities for data-driven decisions.
• Drive process improvements and implement novel approaches.
• Collaborate across multidisciplinary teams and communicate findings clearly.

Skills

Chromatography

AKTA systems

Unicorn software

Analytical techniques

Scientific communication

Team collaboration

Education

BS/MS in Biochemistry/Biophysics/Biomedical/Chemical Engineering

Tools

AKTA chromatography systems

Unicorn software

HPLC

Mass spectrometry

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

Join AbbVie’s Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Youwill leverage yourexpertisetodeliver high-puritymulti-specific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).

Key Responsibilities:

• Leadend-to-end purification campaignsat production-based scalesfordeliveryof high-qualitymulti-specificantibody biologics to support critical researcheffortsandprogramdecisions
• Design and optimize downstream purification strategies using advanced chromatographytechniquestoremove process impurities, mitigate product liabilities, and achieve target quality attributes
• Apply deep analytical expertise to characterize molecules, process intermediates, impurities, and final drug candidates, enabling data-driven process decisions
• Drive scientific innovation and continuousprocessimprovement by identifying and implementing novel approaches that enhance downstream biologics development workflows
• Partner across multidisciplinary teams, translatingprocessinsights into functional resultsto accelerate the advancement of therapeutic candidates
• Communicate scientific findings with clarity and influence,presentingtechnicalinformationto diverse audiencestosupport project progression and knowledge sharing

Qualifications

• BS orMSinBiochemistry, Biophysics,Biomedical, Chemical Engineering,or a related field, with typically 5-7years (BS) or2-5years (MS) of experience
• Demonstrated expertiseinpreparative-scalecolumnchromatographytechniques(i.e.affinity, IEX, HIC, multimodal)forantibody-basedbiologicspurification
• Hands-on experienceoperatingAKTAchromatography systemsand Unicornsoftware
• Strong foundation in analyticalcharacterization techniques, includingHPLC,gelelectrophoresis,ELISA,mass spectrometry, and relatedmethods
• Knowledge of biologicsmanufacturingor processdevelopment is a plus
• Solidunderstandingofprotein structure,molecularattributesand post-translationalmodifications impactingbiologicquality and performance
• Excellent written, verbal, and presentation skills, with the ability to communicate complex scientific concepts to diverse audiences
• Track record of scientific curiosity, innovation, and continuous learning
• Collaborative mindset with a passion for teamwork, scientific rigor, and delivering impactful solutions

Position will be filled at level commensurate with extent of education, experience, and accomplishment— Scientist I or Scientist II

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographiclocation,andwemay ultimately pay more or less than the posted range. This range may bemodified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible toparticipate in our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremains in the Company'ssoleandabsolutediscretion unless and until paid andmay bemodified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:

https://www.abbvie.com/join-us/reasonable-accommodations.html