Bioinformatics Scientist: Nanopore Sensing & ML

Flagship Pioneering; Cambridge (MA); On-site; USD 115,000 - 165,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Job summary

Tilde Bio, Inc. is building a next-generation biological sensing platform that merges biology, physics, and ML.

The Bioinformatics Scientist will join the Computational Team to translate nanopore measurements into actionable scientific insights, designing pipelines beyond standard workflows and enabling platform-scale data interpretation. You will work with experimental scientists to develop methods that transform noisy measurements into robust sequencing outputs, building models that connect

Qualifications

• Master's degree plus 3+ years of industry experience, or PhD in Computational Biology, Biophysics, Bioengineering, Physics, Applied Mathematics, Computer Science, Electrical Engineering.
• Strong programming skills in Python and scientific computing environments.
• Experience analyzing complex biological, physical, or time-series datasets — with noise/variability.
• Solid background in at least two of: statistics, machine learning, signal processing, or Bayesian modeling.
• Comfortable working across experimental and computational domains with wet-lab collaboration.
• Clear scientific communicator — written and verbal.

Responsibilities

• Analyze nanopore and electrophysiology datasets to identify biologically meaningful signal features.
• Develop and implement computational workflows for event detection, classification, and molecular fingerprinting.
• Build quantitative models that connect nanopore measurements to molecular identity, structure, and function.
• Collaborate with experimental scientists to interpret results and shape future experiments.
• Partner with protein science, signal processing, and machine learning teams to improve platform performance.
• Help establish best practices for benchmarking, validation, and uncertainty quantification as the platform scales.

Skills

Python

Statistical modeling

Machine learning

Signal processing

Bayesian modeling

Biophysics

Data analysis

Education

MS + 3+ years in a related field

PhD in Computational Biology/Biophysics/Bioengineering/Physics/Applied Math/CS/EE

Job description

Tilde Bio, Inc. is building a next-generation biological sensing platform that merges biology, physics, and ML.

The Bioinformatics Scientist will join the Computational Team to translate nanopore measurements into actionable scientific insights, designing pipelines beyond standard workflows and enabling platform-scale data interpretation. You will work with experimental scientists to develop methods that transform noisy measurements into robust sequencing outputs, building models that connect