Bioinformatics Scientist: Nanopore Sensing & ML

Flagship Pioneering; Cambridge (MA); On-site; USD 115,000 - 165,000; Full time

Job summary

Tilde Bio, Inc. in Cambridge, MA, is seeking a Bioinformatics Scientist to join our Computational Team and help build the analytical foundation linking nanopore measurements to biological understanding.

You will design and implement pipelines for event detection, classification, and molecular fingerprinting, while collaborating across biology, physics, and ML to turn noisy data into actionable insights.

Qualifications

• Master's degree plus 3+ years of relevant industry experience, or PhD in Computational Biology, Biophysics, Bioengineering, Physics, Applied Mathematics, Computer Science, Electrical Engineering, or a related quantitative discipline.
• Strong programming skills in Python and scientific computing environments.
• Experience analyzing complex biological, physical, or time-series datasets — particularly in the presence of noise and experimental variability.
• Solid background in at least two of: statistics, machine learning, signal processing, or Bayesian modeling.
• Comfortable working across experimental and computational domains; able to engage meaningfully with wet-lab scientists on data interpretation.
• Clear scientific communicator — written and verbal.

Responsibilities

• Analyze nanopore and electrophysiology datasets to identify biologically meaningful signal features.
• Develop and implement computational workflows for event detection, classification, and molecular fingerprinting.
• Build quantitative models that connect nanopore measurements to molecular identity, structure, and function.
• Collaborate with experimental scientists to interpret results and shape the direction of future experiments.
• Partner with protein science, signal processing, and machine learning teams to improve platform performance and analytical capabilities.
• Help establish best practices for benchmarking, validation, and uncertainty quantification as the platform scales.

Skills

Python

Time-series analysis

Statistics

Machine learning

Communication

Education

MS/PhD in Computational Biology or related field

Job description

Tilde Bio, Inc. in Cambridge, MA, is seeking a Bioinformatics Scientist to join our Computational Team and help build the analytical foundation linking nanopore measurements to biological understanding.

You will design and implement pipelines for event detection, classification, and molecular fingerprinting, while collaborating across biology, physics, and ML to turn noisy data into actionable insights.