Bioanalytical LC-MS/MS Chemist — Method Development

LUKOS LLC; Atlanta (GA); On-site; USD 90,000 - 120,000; Full time

Job summary

Lukos seeks a Bioanalytical Chemist to advance clinical and translational research using LC-MS/MS method development and biological specimen processing under BSL-2 protocols. You will quantitate small-molecule drugs across diverse matrices and ensure data integrity and audit readiness.

Ideal candidates hold a BS in Chemistry/Biochemistry with 5–7+ years of hands-on experience; a Master's is preferred. Strong calibration, QA/QC, and compliance with QMML/GLP are essential.

Qualifications

• Hands-on experience developing and validating small-molecule LC-MS/MS assays per FDA/EMA bioanalytical guidelines.
• Experience with sample prep (SPE, LLE, protein precipitation) and complex matrix handling.
• Familiarity with ISO 17025, CLIA, CAP, or GLP standards and QMS/QMML practices.
• Ability to maintain logbooks, IQ/OQ/PQ, and GDP/LIMS/ELN for audit readiness.

Responsibilities

• Process biological and other potentially hazardous specimens for chemical drug analysis.
• Develop and validate new analytical methods to measure small molecular weight compounds in biological specimens.
• Collect, process, aliquot and store biological specimens. Analyze antiretroviral and antimicrobial drug distribution in specimens.
• Calibrate and maintain LC-MS instruments and analytical balances; record calibration for QMS/QMML.
• Perform serologic and molecular assays pertinent to program studies.
• Maintain experiment records, analyze data, and prepare data/results for reports.

Skills

LC-MS/MS

Bioanalysis

Method development

BSL-2 safety

SPE/LLE

qPCR

GLP/QA standards

GDP/LIMS/ELN

Education

Bachelor's in Chemistry/Biochemistry

Master's degree preferred

Job description

Lukos seeks a Bioanalytical Chemist to advance clinical and translational research using LC-MS/MS method development and biological specimen processing under BSL-2 protocols. You will quantitate small-molecule drugs across diverse matrices and ensure data integrity and audit readiness.

Ideal candidates hold a BS in Chemistry/Biochemistry with 5–7+ years of hands-on experience; a Master's is preferred. Strong calibration, QA/QC, and compliance with QMML/GLP are essential.