Automation Scientist, Genome Editing & HT Workflows

Stylus Medicine, Inc.; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team in Cambridge, MA. You will help build automation to accelerate discovery of next-generation gene editing tools and work across R&D to advance recombinase-based platforms.

The role requires hands-on molecular biology, experience with automated liquid handling (Biomek, Mantis, Echo), HT workflows, data analysis, and strong collaboration and communication skills.

Qualifications

• BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field.
• Experience with automated liquid handling systems (Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting.
• Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus.
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Hands-on molecular biology experience, including cloning and RNA production and purification.
• Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling.
• Experience with laboratory inventory management.
• Track record of generating precise, reproducible data and performing rigorous quantitative analysis.
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences.
• Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects.
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact.
• Collaborative mindset with a team-first attitude.
• Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty.

Responsibilities

• Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows.
• Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT).
• Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products.
• Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens.
• Coordinate DNA synthesis and reagent orders with external vendors.
• Manage raw material, plasmid, and RNA inventories.
• Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks.
• Present findings clearly to other teams and contribute to scientific discussions and decision-making.

Skills

Automation experience

HT workflows

Cell-based screening

QC methods

Molecular biology

Data analysis

Inventory management

Communication

Education

BS + 5+ years experience

MS + 2+ years experience

Tools

Biomek

Mantis

Echo

TapeStation

Qubit

NanoDrop

qPCR

Excel

GraphPad Prism

SnapGene

Benchling

Job description

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team in Cambridge, MA. You will help build automation to accelerate discovery of next-generation gene editing tools and work across R&D to advance recombinase-based platforms.

The role requires hands-on molecular biology, experience with automated liquid handling (Biomek, Mantis, Echo), HT workflows, data analysis, and strong collaboration and communication skills.