Associate Scientist, Automation

Stylus Medicine, Inc.; Cambridge (MA); On-site; USD 90,000 - 130,000; Full time

Job summary

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team in Cambridge, MA. You will help build automation to accelerate discovery of next-generation gene editing tools and work across R&D to advance recombinase-based platforms.

The role requires hands-on molecular biology, experience with automated liquid handling (Biomek, Mantis, Echo), HT workflows, data analysis, and strong collaboration and communication skills.

Qualifications

• BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field.
• Experience with automated liquid handling systems (Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting.
• Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus.
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Hands-on molecular biology experience, including cloning and RNA production and purification.
• Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling.
• Experience with laboratory inventory management.
• Track record of generating precise, reproducible data and performing rigorous quantitative analysis.
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences.
• Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects.
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact.
• Collaborative mindset with a team-first attitude.
• Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty.

Responsibilities

• Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows.
• Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT).
• Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products.
• Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens.
• Coordinate DNA synthesis and reagent orders with external vendors.
• Manage raw material, plasmid, and RNA inventories.
• Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks.
• Present findings clearly to other teams and contribute to scientific discussions and decision-making.

Skills

Automation experience

HT workflows

Cell-based screening

QC methods

Molecular biology

Data analysis

Inventory management

Communication

Education

BS + 5+ years experience

MS + 2+ years experience

Tools

Biomek

Mantis

Echo

TapeStation

Qubit

NanoDrop

qPCR

Excel

GraphPad Prism

SnapGene

Benchling

Job description

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities:

Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows.

Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT).

Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products.

Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens.

Coordinate DNA synthesis and reagent orders with external vendors.

Manage raw material, plasmid, and RNA inventories.

Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks.

Present findings clearly to other teams and contribute to scientific discussions and decision-making.

Qualifications & Skills:

BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field.

Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting.

Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus.

Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.

Hands-on molecular biology experience, including cloning and RNA production and purification.

Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling.

Experience with laboratory inventory management.

Track record of generating precise, reproducible data and performing rigorous quantitative analysis.

Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences.

Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects.

Strategic thinker who effectively plans and prioritizes to maximize scientific impact.

Collaborative mindset with a team-first attitude.

Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty.

200 Technology Square, Suite 800, Cambridge, MA 02139

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