Senior Research Associate, Genome Editing & High-Throughput Screening

Stylus Medicine, Inc.; Cambridge (MA); On-site; USD 100,000 - 110,000; Full time

Job summary

Stylus Medicine is seeking a Senior Research Associate to join our Genome Sciences & Engineering team in Cambridge, MA. You will drive the execution of cell-based assays and high-throughput screening workflows to advance our LSR-based genome editing platforms.

This role favors a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. Pay range is $100,000–$110,000 per year.

Qualifications

• BS with 3+ years or MS with 1+ years relevant experience in cell biology, molecular biology, or a related field.
• Experience conducting high-throughput cell-based screens; proficiency with primary T cells, hepatocytes, and/or cancer cell lines, working with LNPs preferred.
• Hands-on experience with gene editing technologies (e.g. CRISPR nucleases, recombinases, base editors, or transcriptional effectors).
• Familiarity with laboratory automation platforms for cell-based screening workflows, flow cytometry.
• Experience with nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR.
• Track record of independently generating precise, reproducible data and performing rigorous quantitative analysis.
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences.
• Exceptional organizational skills and comfort managing complex datasets and overlapping projects.
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact.
• Collaborative mindset with a team-first attitude.
• Creative problem-solver who thrives amid scientific uncertainty.

Responsibilities

• Execute cell-based assays and high-throughput (HT) screening workflows that advance platform and program objectives, working both independently and as part of a cross-functional team
• Develop and execute arrayed and pooled HT screening campaigns with rigor and reproducibility
• Troubleshoot experiments, analyze data, and translate results into actionable scientific insights
• Maintain detailed laboratory notebooks and clearly communicate data and findings to the broader scientific team
• Partner cross-functionally to advance optimized candidates into translational and preclinical development

Skills

Cell biology

Molecular biology

Gene editing

HT screening

LNPs

Data analysis

Communication

Organization

Collaboration

Problem solving

Education

BS in cell biology or related field

MS in cell biology or related field

Tools

Flow cytometry

TapeStation

Qubit

NanoDrop

qPCR

Automation platforms

Job description

Stylus Medicine is seeking a Senior Research Associate to join our Genome Sciences & Engineering team in Cambridge, MA. You will drive the execution of cell-based assays and high-throughput screening workflows to advance our LSR-based genome editing platforms.

This role favors a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. Pay range is $100,000–$110,000 per year.