Associate Scientist, Automation

stylusmedicine; Cambridge (MA); On-site; USD 105,000 - 120,000; Full time

Job summary

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team to build automation capabilities that accelerate development of next-generation gene editing tools. This role suits a collaborative, organized scientist who thrives in a fast-paced environment and tackles complex problems.

This position focuses on advancing recombinase-based genome editing platforms and coordinating with diverse R&D teams to drive discovery and engineering

Qualifications

• BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
• Experience with automated liquid handling systems and HT workflows including method development and troubleshooting
• Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
• Hands-on molecular biology experience, including cloning and RNA production and purification
• Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
• Experience with laboratory inventory management
• Track record of generating precise, reproducible data and performing rigorous quantitative analysis
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
• Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact
• Collaborative mindset with a team-first attitude
• Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty

Responsibilities

• Develop automation capabilities that support reagent generation and HT screening workflows
• Optimize automated HT workflows for plasmid cloning and IVT RNA generation
• Develop and run QC assays to sequence-verify plasmid constructs and assess IVT product integrity
• Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
• Coordinate DNA synthesis and reagent orders with external vendors
• Manage raw material, plasmid, and RNA inventories
• Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
• Present findings clearly to other teams and contribute to scientific discussions and decision-making

Skills

Automated liquid handling

High-throughput workflows

Flow cytometry (bonus)

Nucleic acid QC methods

Molecular cloning

RNA production and purification

Data analysis tools (Excel, GraphPad,–

Benchling

Inventory management

Scientific communication

Project management

Education

Bachelor’s degree in life sciences or related

Master’s degree in life sciences or related

Tools

Biomek

Mantis

Echo liquid handler

qPCR instruments

Job description

About Stylus Medicine

Stylus Medicine is developing transformative in vivo genetic medicines to unlock cures. Stylus combines engineered recombinases with non-viral delivery to specifically encode therapeutics. The company's approach is versatile and modular, with potential therapeutic application across oncology, autoimmune, genetic diseases, and beyond.

About the Role

Stylus Medicine is seeking an Associate Scientist, Automation to join our Genome Sciences & Engineering team and build automation capabilities that accelerate the development of our next-generation gene editing tools. This role is ideal for a collaborative, organized, and creative scientist who thrives in a fast-paced environment and enjoys tackling complex problems to expand the frontiers of genome editing. This individual will play a key role in discovery and engineering efforts, advancing recombinase-based genome editing platforms and collaborating across diverse R&D teams.

Key Responsibilities & Accountabilities

• Develop automation capabilities that support reagent generation and high-throughput (HT) screening workflows
• Optimize automated HT workflows for plasmid cloning and RNA generation via in vitro transcription (IVT)
• Develop and run QC assays to sequence-verify plasmid constructs and assess the integrity of IVT products
• Partner with screening scientists to automate plate preparation, reagent dispensing, and assay setup for cell-based HT screens
• Coordinate DNA synthesis and reagent orders with external vendors
• Manage raw material, plasmid, and RNA inventories
• Maintain detailed documentation of protocols, methods, and results in electronic lab notebooks
• Present findings clearly to other teams and contribute to scientific discussions and decision-making

Qualifications & Skills

• BS with 5+ years or MS with 2+ years of full-time industry or academic research experience in life sciences, biology, biochemistry, engineering, or a related field
• Experience with automated liquid handling systems (e.g., Biomek, Mantis, Echo) and high-throughput laboratory workflows, including method development and troubleshooting
• Familiarity with automating cell-based screening workflows; experience with flow cytometry is a plus
• Proficiency in nucleic acid QC methods, including TapeStation, Qubit, NanoDrop, and qPCR
• Hands-on molecular biology experience, including cloning and RNA production and purification
• Working knowledge of data analysis and information management tools such as Excel, GraphPad Prism, SnapGene, and Benchling
• Experience with laboratory inventory management
• Track record of generating precise, reproducible data and performing rigorous quantitative analysis
• Clear and approachable communication skills, with the ability to present technical information clearly and concisely to diverse audiences
• Exceptionally organized and comfortable managing large sample sets, inventories, and overlapping projects
• Strategic thinker who effectively plans and prioritizes to maximize scientific impact
• Collaborative mindset with a team-first attitude
• Resourceful problem-solver who enjoys troubleshooting instruments and workflows and thrives amid scientific uncertainty

Pay Range: $105,000 - $120,000