Associate Director, Pharmacology - Bone Health Biologics

AmpersandPeople, Inc.; San Francisco (CA); On-site; USD 180,000 - 260,000; Full time

Job summary

AmpersandPeople, Inc. in San Francisco, CA is seeking an Associate Director of Pharmacology to drive preclinical pharmacology across a growing bone health biologics pipeline.

You will lead in vivo study operations with CROs, design integrated pharmacology strategies, and contribute to regulatory filings and translational biomarker development. You will collaborate with Protein Engineering, Translational Medicine, and Toxicology to align dosing and clinical translation plans, while presenting

Qualifications

• PhD in Pharmacology, Bone Biology, Physiology, Pharmaceutical Sciences, or related field with 4+ years in biopharma preclinical pharmacology.
• Proven track record supporting or leading pharmacology strategies across multiple biologic programs.
• Experience managing externalized research workflows and CRO partnerships without internal vivarium.
• Skilled in selecting statistical tests for in vivo pharmacology, biomarker evaluation, PK/PD data analysis.
• Experience authoring pharmacology sections in IND/CTA filings.
• Proficient with GraphPad Prism, Spotfire, Phoenix WinNonLin and ELN/LIMS.
• Excellent communication to summarize data for leadership.

Responsibilities

• Lead day-to-day operations, scheduling, sample management, and tracking of in vivo studies with external contract research organizations (CROs).
• Formulate and execute integrated preclinical pharmacology strategies across multiple development programs, establishing clear drug exposure, target engagement, and efficacy models.
• Author and review high-quality study protocols, study reports, and pharmacology components of regulatory packages (IND/CTA submissions and Investigator’s Brochures).
• Drive the evaluation, validation, and implementation of novel disease models and translational biomarkers to elucidate mechanism-of-action across target candidates.
• Analyze and interpret complex biological and PK/PD datasets to pressure-test scientific hypotheses and deliver actionable go/no-go recommendations to leadership.
• Partner closely with Protein Engineering, Translational Medicine, and Toxicology teams to align on biological candidate profiling, dose selection rationale, and clinical translation plans.
• Present comprehensive data packages, program updates, and strategic risk-mitigation plans to internal leadership.

Skills

Leadership

Program management

External CRO management

Data analysis

Regulatory communication

Education

PhD in Pharmacology or related field

MS in Pharmacology or related field

Tools

GraphPad Prism

Spotfire

Phoenix WinNonLin

ELN/LIMS systems

Job description

AmpersandPeople, Inc. in San Francisco, CA is seeking an Associate Director of Pharmacology to drive preclinical pharmacology across a growing bone health biologics pipeline.

You will lead in vivo study operations with CROs, design integrated pharmacology strategies, and contribute to regulatory filings and translational biomarker development. You will collaborate with Protein Engineering, Translational Medicine, and Toxicology to align dosing and clinical translation plans, while presenting