Principal Clinical Scientist

Alignerr Corp.; Portugal; Remote; EUR 138,000 - 193,000; Part time

Benefits offered by this job

Fully remote work

Flexible schedule

Job summary

Alignerr is seeking a Principal Clinical Scientist to shape AI training using regulatory-grade clinical data. This fully remote, hourly-contract role demands senior expertise in trial design and regulatory science to ensure AI systems are built on scientifically sound data for biomedical research.

You will design protocols, audit results, and evaluate AI-driven analyses to guarantee regulatory relevance across therapeutic areas, with flexible scheduling and meaningful, high-impact work.

Qualifications

• Senior-level professional with hands-on experience designing clinical trial protocols for regulatory submission.
• Deep experience interpreting clinical data for agencies such as FDA/EMA or equivalent bodies.
• Strong background in clinical research methodology, biostatistics, or translational science.
• Able to maintain rigorous standards in AI-generated content and ensure regulatory alignment.
• Self-directed and capable of delivering high-quality work independently.

Responsibilities

• Design and review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training.
• Interpret and audit clinical trial results to ensure accuracy and regulatory compliance.
• Evaluate AI-generated analyses for scientific soundness and regulatory relevance.
• Provide expert feedback to improve how AI models reason about clinical trial data, endpoints, and outcomes.
• Help establish scientific credibility of AI outputs in clinical contexts.

Skills

Clinical trial design

Regulatory science

Biostatistics

Translational science

AI training data

Regulatory submissions

Tools

AI tools

Clinical NLP systems

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your career-long expertise in clinical trial design and regulatory science could directly shape how AI reasons about medical evidence for millions of patients worldwide?

We're looking for a Principal Clinical Scientist to bring senior-level rigor to cutting-edge AI research workflows. In this role, your deep knowledge of regulatory-grade clinical data will help ensure that the AI systems influencing biomedical research are built on a foundation of scientific integrity — the kind that holds up to real-world scrutiny.

This is a fully remote, flexible contract role designed for experienced clinical scientists who want meaningful, high-impact work on their own schedule.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and critically review clinical trial protocols used to generate high-quality, regulator-ready datasets for AI training
• Interpret and audit clinical trial results to ensure accuracy, consistency, and alignment with regulatory standards
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory relevance
• Provide expert feedback that directly improves how AI models reason about clinical trial data, endpoints, and outcomes
• Help establish the scientific credibility of AI outputs in clinical and biomedical contexts

Who You Are

• Senior-level professional with hands-on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for agencies such as the FDA, EMA, or equivalent global bodies
• Strong background in clinical research methodology, biostatistics, or translational science
• Naturally rigorous — you hold AI-generated content to the same standards you'd apply in a real submission
• Self-directed and comfortable delivering high-quality work independently

Nice to Have

• Prior experience with data annotation, data quality evaluation, or AI training workflows
• Familiarity with AI tools or clinical NLP systems as an end user
• Experience spanning multiple therapeutic areas or regulatory jurisdictions
• Background in academic clinical research, CRO environments, or regulatory consulting

Why Join Us

• Work directly on frontier AI systems that are reshaping clinical and biomedical research
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level work
• Influence how AI understands, evaluates, and communicates real-world clinical evidence at scale
• Potential for ongoing work and contract extension as new projects launch