Senior Scientist - High Throughput Screening

Selvita; Kraków; On-site; PLN 180,000 - 240,000; Full time

Job summary

Selvita in Kraków, Poland, seeks a Senior Scientist for High Throughput Screening to lead large HTS campaigns with 200,000+ compounds. You will develop and optimize assays, transfer to automated HTS formats, and ensure data quality while collaborating across biology, chemistry, automation, and data science teams.

Ideal candidates have a PhD and 5+ years in biotech, pharma, or CROs, with strong ELN usage and experience in hit triage, confirmation, and profiling workflows.

Qualifications

• PhD in biology, pharmacology, molecular biology, or related life sciences.
• Minimum 5 years of industrial experience in biotech, pharma or CROs.
• Proven leadership of large-scale HTS campaigns (200,000+ compounds).
• Hands-on experience in biochemical and/or cell-based assay development and optimization.

Responsibilities

• Lead large-scale biochemical and cell-based HTS campaigns in 384- and 1536-well formats (200,000+ compounds).
• Define screening strategies, assay requirements, controls, and quality criteria.

Skills

HTS leadership

English communication

Education

PhD in Biology/Pharmacology/Biochem

Tools

ELN

Data management systems

Automated liquid handling

Job description

Senior Scientist - High Throughput Screening

Selvita

Kraków, Poland

We are seeking an experienced Senior Scientist – High Throughput Screening (HTS) to join our In Vitro Pharmacology Oncology team.

This role is ideal for a scientifically driven professional with strong hands‑on experience in designing, executing, analyzing, and troubleshooting large‑scale HTS campaigns. The primary focus will be on delivering HTS projects in a CRO environment, including campaigns involving 200,000+ compounds, while contributing to assay development, automation, and hit identification workflows.

The successful candidate will become a key HTS expert within the organization, supporting scientific excellence, data quality, process development, and collaboration across multidisciplinary project teams.

Key Responsibilities

High-Throughput Screening Leadership

• Lead and execute large-scale biochemical and cell-based HTS campaigns in 384- and 1536-well formats, including campaigns involving 200,000+ compounds.


• Define screening strategies, assay requirements, controls, and quality criteria.


• Oversee campaigns from assay transfer and screening execution through hit identification and confirmation.


• Ensure high-quality project delivery in line with timelines and client expectations.

Assay Development and Optimization

• Develop, optimize, miniaturize, and validate biochemical and cell-based assays for HTS applications.


• Transfer assays into automated, HTS-compatible formats.


• Optimize assay robustness and performance and ensure high-quality screening data.-

Scientific and Technical Oversight

• Interpret screening data, troubleshoot technical issues, and drive improvements in assay and screening performance.


• Support hit triage, confirmation, counter-screening, and follow‑up characterization.


• Contribute to the development of new HTS approaches, technologies, and workflows.

Quality and Process Excellence

• Ensure compliance with internal SOPs, quality standards, and documentation requirements.


• Contribute to the development and continuous improvement of HTS processes, quality controls, and operational standards.

Cross‑Functional and Client Collaboration

• Collaborate with biology, chemistry, automation, and data science teams to support client projects.


• Provide scientific input during project planning, study design, and proposal preparation.


• Present project updates and scientific findings to internal stakeholders and external clients.


• Act as an HTS subject matter expert within multidisciplinary project teams.

Mentoring

• Mentor junior scientists and laboratory staff.


• Provide technical guidance in assay development, screening execution, troubleshooting, and data interpretation.


• Contribute to building HTS expertise across the organization.

Your Background

• PhD in Biology, Biotechnology, Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.


• Minimum 5 years of relevant industrial experience in biotechnology, pharmaceutical, or CRO environments.


• Proven experience leading large-scale high-throughput screening campaigns, ideally involving 200,000+ compounds.


• Strong hands‑on experience in biochemical and/or cell‑based assay development and optimization.


• Experience with automated liquid handling and screening platforms.


• Strong understanding of HTS assay quality, validation, experimental design, and data analysis.


• Experience with hit identification, confirmation, and profiling workflows.


• Experience working with electronic laboratory notebooks (ELN) and data management systems.


• Excellent written and verbal communication skills in English.

Preferred Qualifications

• Experience with Echo acoustic dispensing systems.


• Experience with automated screening platforms and robotic workflows.


• Experience working directly with external clients in a CRO environment.


• Previous experience mentoring or supervising scientists.