Research Fellow – gene editing and cell-based therapy

Stipendiat; Oslo; On-site; NOK 565,000 - 595,000; Full time

Benefits offered by this job

Research environment

Pension benefits

Welfare schemes

Family-friendly Oslo

Pensjonskasse membership

Exercise during work hours

Career development

Job summary

The University of Oslo invites applications for a 6-month position in a project on cell-based therapy for inherited bleeding disorders. The work is based at Oslo University Hospital, Rikshospitalet, within the Institute of Clinical Medicine, Division of Cancer Medicine.

The project focuses on inherited factor VII (FVII) deficiency and applies advanced technologies such as CRISPR-based gene editing, induced pluripotent stem cells and liver organoids to rescue FVII expression in patient-derived

Qualifications

• MSc (or equivalent) in a relevant discipline (e.g. medicine, molecular biology, cell biology, biotechnology or similar).
• Demonstrated ability to design, plan and execute in vitro and in vivo experiments.
• Formal accreditation for work with animal models (e.g. FELASA C or equivalent) AND experience with mouse surgery and xenotransplant.
• Experience with stem cell work and stem cell-derived 3D hepatic organoid differentiation.
• Proficiency in English, both written and oral.

Responsibilities

• Support continued experimental work and data analysis within in vivo pre-clinical studies.
• Contribute actively to experimental design, execution and troubleshooting, as well as interpretation and reporting of results.

Skills

Experimental design

Animal work

English proficiency

Team collaboration

Independent work

Education

MSc or equivalent in relevant discipline

Tools

FELASA C accreditation

Mouse surgery

Xenotransplant

Job description

About the position

We invite applications for a 6‑month position in our project on cell-based therapy for inherited bleeding disorders.

The position is part of an ongoing project funded by the Norwegian Research Council and affiliated with the Institute of Clinical Medicine, Division of Cancer Medicine, University of Oslo, with daily work based at Oslo University Hospital, Rikshospitalet.

The research group has long-standing expertise in basic, translational and clinical research on blood coagulation factors and their role in disease.

More about the position

The project focuses on inherited factor VII (FVII) deficiency, a rare but serious bleeding disorder caused by mutations in the F7 gene, leading to markedly reduced FVII activity, and applies advanced technologies such as CRISPR-based gene editing, induced pluripotent stem cells and liver organoids to rescue the FVII expression in patient-derived cells.

The position will support continued experimental work and data analysis within in vivo pre-clinical studies, which form an important foundation for future cell-based therapies in patients with FVII deficiency.

The research fellow is expected to contribute actively to experimental design, execution and troubleshooting, as well as to the interpretation and reporting of results.

Qualifications

Qualification requirements

• MSc (or equivalent) in a relevant discipline (e.g. medicine, molecular biology, cell biology, biotechnology or similar).
• Demonstrated ability to design, plan and execute in vitro and in vivo experiments.
• Formal accreditation for work with animal models (e.g. FELASA C or equivalent) AND experience with mouse surgery and xenotransplant.
• Experience with stem cell work and stem cell-derived 3D hepatic organoid differentiation.
• Proficiency in English, both written and oral.

Persoonal skills

• We are looking for a candidate who is:
• Highly motivated and enthusiastic about translational research
• Organized, structured and able to work independently
• Flexible
• A team player with excellent communication and collaboration skills

We need different perspectives in our work

UiO is an open and internationally oriented comprehensive university that strives to be an inclusive and diverse workplace and academic environment. You can read more about UiO’s work on equality, inclusion, and diversity at uio.no .

We fulfill our mission most effectively when we draw upon our variety of experiences, backgrounds, and perspectives. We are looking for great colleagues—could you be the next one?

We will provide appropriate accommodations should you need them. Relevant adjustments may include modifications to working hours, task adaptations, digital, technical, or physical adjustments, or other practical measures.

If you have an immigrant background, a disability, or CV gaps, we encourage you to indicate this in the job application portal. We always invite at least one qualified candidate from each group for an interview. In this context, disability is defined as an applicant who identifies as having a disability that requires workplace or employment-related accommodations. For more details about the requirements, please refer to the Employer portal (Norwegian).

The selections made in the job application portal are used for anonymized statistics that all state employers include in their annual reports.

More information about gender equality initiatives at UiO can be found here.

We offer

• An exciting research environment with opportunities for academic development.
• Attractive welfare benefits and a generous pension agreement
• Good welfare schemes.
• in addition to Oslo’s family-friendly environment with its rich opportunities for culture and outdoor activities.
• Membership in the Statens Pensjonskasse , which is one of Norway's best pension schemes with beneficial mortgages and good insurance schemes.
• Opportunity of up to 1.5 hours a week of exercise during working hours.
• A workplace with good development and career opportunities.
• Salary in position as researcher, position code 1108 in salary range NOK 565000 to 595 000 depending on competence and experience. From the salary, 2 percent is deducted in statutory contributions to the State Pension Fund

Application

• Application letter
• CV
• A complete list of publications
• Transcripts and certificates
• Contact information for 2-3 references

General information

Please note that we are unable to add documentation after the application deadline. As the deadline applies equally to all applicants, this policy ensures equal treatment throughout the recruitment process. If you experience difficulties uploading documents in Jobbnorge, please contact their customer service: Phone: [phone] or Email: [e-mail]

The best qualified candidates will invited for interviews.

Applicant lists can be published in accordance with Norwegian Freedom of Information Act § 25. When you apply for a position with us, your name will appear on the public applicant list. It is possible to request to be excluded from this list. You must justify why you want an exemption from publication and we will then decide whether we can grant your request. If we cannot, you will hear from us.

Please refer to Regulations for the Act on universities and colleges chapter 3 (Norwegian) and Rules for the use of research posts SKO 1108, 1109, 1110 and 1183 at UiO.

The University of Oslo has a transfer agreement with all employees to secure the rights to all research results and related intellectual property.

Contact information

For scientific questions about the position:

• Project leader, Benedicte Stavik – e‑mail: [e-mail]
• Maria Eugenia Chollet Dugarte – e‑mail: [e-mail]

For questions regarding the electronic application form:

• HR Adviser Maren Retterstøl Olaisen –

e‑mail: [e-mail]