Proteomics Specialist

Human Technopole; Milano; Hybrid; EUR 47,000 - 57,000; Full time

Job summary

Human Technopole in Milan seeks a Proteomics Specialist to lead advanced proteomics workflows and operate MS platforms for high-throughput studies on cells, organoids, tissues and biofluids.

You will analyze data, support users, contribute to experimental design, and mentor junior staff while helping develop SOPs and QA parameters for reporting and auditing.

Qualifications

• PhD in biology, biochemistry, chemistry or related field.
• Experience with plasma, spatial/tissue, clinical, or single-cell proteomics is a plus.
• Experience implementing proteomics methods on mass spectrometry platforms.
• Ability to design and optimize experiments and oversee large studies.

Responsibilities

• Develop and optimize advanced proteomics workflows and protocols.
• Operate and maintain mass spectrometry platforms and automation.
• Manage large-scale proteomics studies with high throughput.
• Analyze data and support facility users; contribute to experimental design.
• Mentor junior staff and contribute to SOPs and QA processes.

Skills

Proteomics

Mass spectrometry

Data analysis

Project coordination

Mentoring

Education

PhD in biology/biochemistry/chemistry

Tools

LC-MS platforms

Mass spectrometers

Job description

Build the science that shapes the future of human health.
Application closing date: 08 November 2026

Join a place where ambitious science thrives

Human Technopole (Milan) is a rapidly expanding life science institute where international researchers and cutting-edge technologies converge to accelerate biomedical discovery. Our mission is to transform bold scientific ideas into advances that improve human health.

Within this mission, The Structural Proteomics Unit studies protein structure and interactions using advanced mass spectrometry–based proteomics, with a strong focus on crosslinking MS and high-throughput workflows, including single-cell proteomics. It operates state-of-the-art instrumentation and advanced data analysis pipelines within the multidisciplinary ecosystem of Human Technopole. the Proteomics Specialist will report to the Unit Manager and collaborate closely with National Facilities and research groups. The focus of the Proteomics Specialist will be to support high throughput proteomics of cell lines, organoids, tissues and biofluids, together with the other members of the team.

Your mission

• Develop and optimize advanced proteomics workflows
  Establish robust protocols for spatial/visual, plasma and clinical proteomics, including bottom-up sample preparation pipelines and peptide enrichment strategies.
• Operate and maintain mass spectrometry platforms
  Perform instrument calibration, cleaning, basic maintenance, and support automation of peptide extraction, digestion, and cleanup for diverse sample types.
• Manage large-scale proteomics studies
  Oversee processing and data acquisition for high-throughput projects involving hundreds to thousands of samples, ensuring quality and reproducibility.
• Analyze data and support facility users
  Deliver and explain results to users, contribute to experimental design and project planning, provide technical support during projects, and train internal and external researchers.
• Contribute to the growth of the Unit
  Support resource planning, introduce new protocols and applications, collaborate with vendors and service engineers, mentor junior staff, and participate in facility reviews and research initiatives.
• Support facility operations and quality assurance
  Manage facility digital platforms and software, support procurement and inventory monitoring, perform advanced troubleshooting of protocols and technical issues, contribute to the development and implementation of Standard Operating Procedures (SOPs) and quality assurance parameters for reporting and auditing.
• Support facility operations and quality assurance
  Manage facility software, support procurement and inventory monitoring, perform advanced troubleshooting of protocols and technical issues.

Grow your skills

You will enhance your scientific and professional skills by working with:

• cutting-edge proteomics technologies, including state-of-the-art mass spectrometry platforms, automation, and advanced workflows for single-cell, spatial, and clinical proteomics.
• complex experimental design and large-scale data generation, ensuring high-quality, reproducible results in a high-throughput facility environment.
• multidisciplinary collaboration and facility operations, developing expertise in project coordination, user support, technology development, and mentoring within a leading research infrastructure.

Human Technopole supports career development through training, mentoring and dedicated learning opportunities.

What you'll bring

• PhD in a relevant subject (e.g. biology, biotechnology, biochemistry, chemistry) to be obtained within the deadline of the call.
• One or more of the following: experience with plasma proteomics, spatial/tissue proteomics, clinical proteomics, single cell proteomics
• Experience with implementing mass spec/proteomics methods at the spectrometer.
• Familiarity with operating and troubleshooting LC-MS platforms.

Preferred

Any one of the following:

• Experience with DIA for global untargeted proteomics
• Familiarity with Astral, Hybrid or Tribrid Mass Spectrometers.
• Experience in working with large cohorts and/or patient sample sets, including benchmarking and QC.
• Experience in standardising workflows and/or developing targeted assays.
• Experience with machine learning in proteomics data analysis.
• Experience with spatial proteomics workflows

Organizational and social skills:

• Communication, team building and problem‑solving skills;
• Ability to interact effectively with other teams and work synergistically to effectively drive projects.
• Highly organised and meticulous work attitude.
• Motivation to mentor and train.

At HT, your discoveries contribute to a global effort to improve human health.

Why Human Technopole

HT offers an international and dynamic workplace, competitive welfare provisions, flexible working policies and relocation support. Researchers relocating to Italy may benefit from attractive tax benefits. We promote work–life balance and provide parental support initiatives.

This is a 3-year contract offered under CCNL Chimico Farmaceutico, Level B2

Salary: up to € 52.000,00 depending on the candidate’ seniority.
The position is based in Milan, Italy, within our vibrant international campus.
We strongly encourage applications from candidates belonging to protected categories (L. 68/99).

Information at a Glance Legal Entity: Fondazione Human Technopole Area: Scientific Operations Unit of Service: Scientific Facilities