Medicinal Chemist

Bioplus Life Sciences Pvt. Ltd.; India; On-site; INR 3,500,000 - 6,000,000; Full time

Job summary

Bioplus Life Sciences in India seeks an experienced Medicinal Chemist with a Ph.D./M.Sc. in Organic, Medicinal, or Pharmaceutical Chemistry and 10–15 years in medicinal chemistry. You will design, synthesize, purify and characterize novel chemical entities for drug discovery programs.

You will collaborate with biology, analytical, DMPK, and formulation teams to optimize potency, selectivity, and drug-like properties, while ensuring proper documentation and regulatory compliance.

Qualifications

• Ph.D./M.Sc. in Organic, Medicinal, or Pharmaceutical Chemistry with 10–15 years in medicinal chemistry.
• Experience in design, synthesis, purification, and characterization of drug-like molecules.

Responsibilities

• Design and synthesize small molecules and analogs based on SAR studies.
• Purify compounds using chromatography and related techniques.
• Characterize compounds with NMR, MS, LC-MS, and related methods.
• Support lead optimization and hit-to-lead programs.
• Collaborate with biology, analytical, DMPK/ADME, and formulation teams.
• Maintain lab notebooks, reports, and comply with GLP/GMP where applicable.

Skills

Organic synthesis

Multi-step synthesis

Purification techniques

Spectral data interpretation

SAR & medicinal chemistry

Education

Ph.D./M.Sc. in Organic, Medicinal, or Pharmaceutical Chemistry

Tools

NMR

LC-MS/GC-MS

HPLC

IR spectroscopy

Job description

Ph.D./M.Sc. in Organic, Medicinal, or Pharmaceutical Chemistry.

10-15 years of relevant experience in medicinal chemistry / drug discovery

The Medicinal Chemist will be responsible for the design, synthesis, purification, and characterization of novel chemical entities for drug discovery programs. The role involves working closely with biology, analytical, DMPK, and formulation teams to optimize compounds for potency, selectivity, and drug-like properties.

Key Responsibilities

• Drug Design & Synthesis
  • Design and synthesize small molecules and analogs based on SAR (Structure-Activity Relationship) studies.
  • Develop efficient synthetic routes for target molecules.
  • Optimize synthetic methodologies for yield, purity, and scalability.
• Compound Characterization & Analysis
  • Purify compounds using chromatography and related techniques.
  • Characterize compounds using:
  • NMR
  • LC-MS / GC-MS
  • HPLC
  • IR spectroscopy
  • Maintain high-quality documentation of analytical data.
• Research & Development
  • Conduct literature reviews and patent searches to identify innovative approaches.
  • Analyze biological assay results and recommend structural modifications.
  • Support lead optimization and hit-to-lead programs.
• Cross-Functional Collaboration
  • Work with:
  • Biology teams for activity feedback
  • Analytical teams for compound purity validation
  • DMPK/ADME teams for optimization of drug-like properties
  • Participate in scientific discussions and project review meetings.
• Documentation & Compliance
  • Maintain accurate laboratory notebooks and experimental records.
  • Prepare technical reports and presentations.
  • Ensure compliance with:
  • GLP/GMP (where applicable)
  • Laboratory safety standards
  • Regulatory and company SOPs
• Stay updated with emerging medicinal chemistry techniques.
• Propose innovative synthetic strategies and process improvements.

Skills Required

• Strong expertise in organic synthesis and reaction mechanisms
• Experience in multi-step synthesis
• Hands-on knowledge of purification techniques
• Interpretation of spectral data (NMR, Mass, IR)
• Knowledge of SAR and medicinal chemistry principles