Senior Antibody Engineer — Developability & Biophysics Lead

LabGenius; Greater London; On-site; GBP 90,000 - 130,000; Full time

Benefits offered by this job

Discretionary bonus

Equity stock options

Pension contribution

Life Assurance

Job summary

LabGenius Therapeutics in London seeks a technical lead for antibody characterisation to drive developability and binding studies. You will design workflows, run high-resolution assays, and feed ML models with high-quality data from state-of-the-art instruments.

You will work within the Antibody Engineering and Developability team, collaborating across discovery, data science, and automation. A PhD with wet-lab expertise or an MSc with extensive experience is required.

Qualifications

• PhD in protein/antibody engineering or MSc with 3–5 years of wet-lab experience in protein characterisation.
• Extensive experience with thermostability assays (DSF), self-association, DLS and analytical UPLC/HPLC (SE-HPLC, HIC-HPLC).
• Strong MS data analysis skills for antibody characterisation (intact mass, peptide mapping).
• Hands-on experience with BLI (Octet), including biosensor selection and immobilisation strategies.
• Experience characterising non-traditional modalities like bispecifics, VHH, or scaffold proteins, and complex binding interactions.
• Proficiency in analytical data software and understanding of structure-function relationships and PTM liabilities.
• Ability to design new lab infrastructure and automated workflows, and articulate complex data to non-experts.
• Excellent organisational and time management skills; ability to prioritise and meet timelines.

Responsibilities

• Act as central contact between protein production, discovery, and data science for robust characterisation of candidates.
• Perform/interpret diverse analytical assays (HPLC, MS, thermal stability, self-association) to build developability profiles.
• Design and run high-resolution BLI campaigns to determine binding kinetics and mapping.
• Collaborate with Lab Automation to integrate workflows toward autonomous characterisation.
• Translate biophysical readouts into clean datasets for ML/AI models.
• Develop automated biophysical screening assays using 96/384-well formats.
• QC analyse and troubleshoot developability experiments with R&D teams.
• Conduct self-directed research to resolve analytical bottlenecks and provide actionable insights.
• Keep meticulous experimental/data records for cross-functional teams.
• Organise time effectively to deliver on timelines.

Skills

Thermostability assays

Self-association assessments

Dynamic light scattering

UPLC/HPLC techniques

Mass spectrometry data analysis

BLI assay execution

Binding kinetics (kon/koff/KD)

Automation/workflow design

Data interpretation for ML/AI datasets

Communication of complex data

Time management

Self-motivation and adaptability

Education

PhD in protein/antibody engineering

MSc with 3–5 years wet-lab experience

Tools

BLI (Octet)

UHPLC/HPLC

MS data analysis software

96- and 384-well screening formats

Job description

LabGenius Therapeutics in London seeks a technical lead for antibody characterisation to drive developability and binding studies. You will design workflows, run high-resolution assays, and feed ML models with high-quality data from state-of-the-art instruments.

You will work within the Antibody Engineering and Developability team, collaborating across discovery, data science, and automation. A PhD with wet-lab expertise or an MSc with extensive experience is required.