Lead Antibody Biophysics & Developability Scientist

LabGenius Therapeutics; Greater London; On-site; GBP 75,000 - 110,000; Full time

Benefits offered by this job

Discretionary bonus

Stock options

Pension 5% company contribution

Life Assurance 3x salary

Private medical insurance

Job summary

LabGenius Therapeutics in London is seeking a versatile antibody characterisation scientist to drive developability analytics and collaborate with ML-driven discovery. You will design workflows, run high-resolution assays, and help build an automated platform to feed predictive models and advance our solid tumour pipeline.

This full-time role blends wet-lab expertise with cross-functional teamwork, shaping a scalable biophysics program, mentoring scientists, and contributing to lead optimisation

Qualifications

• PhD in protein/antibody engineering or MSc with 3–5 years wet-lab experience.
• Experience across thermostability assays (DSF), self-association, DLS, and SE-HPLC/HIC-HPLC.
• MS data analysis for antibody characterization (intact mass, peptide mapping).
• Hands-on BLI (Octet) including biosensor selection and regeneration optimization.

Responsibilities

• Act as central contact between protein production, discovery, and data science to characterize candidates.
• Perform and interpret analytical assays including HPLC, MS, thermal stability, and self-association to build developability profiles.
• Design and run high-resolution BLI screens to determine kon/koff/KD and map epitopes.
• Collaborate with Lab Automation to integrate liquid handling with BLI/HPLC workflows for autonomous characterization.
• Work with Data Science to translate biophysical readouts into clean ML-ready datasets.
• Design and implement automated biophysical screening assays using 96- and 384-well formats.

Skills

HPLC analysis

Mass spectrometry

Biophysical assays

BLI (Octet)

Data interpretation

Lab automation

Education

PhD in protein/antibody engineering

MSc with 3-5 years industrial wet-lab experience

Tools

BLI instruments (Octet)

UHPLC

MS data analysis software

Job description

LabGenius Therapeutics in London is seeking a versatile antibody characterisation scientist to drive developability analytics and collaborate with ML-driven discovery. You will design workflows, run high-resolution assays, and help build an automated platform to feed predictive models and advance our solid tumour pipeline.

This full-time role blends wet-lab expertise with cross-functional teamwork, shaping a scalable biophysics program, mentoring scientists, and contributing to lead optimisation