Lead Scientist, Antibody Discovery & Engineering

Orion Pharma; Cambridge; On-site; GBP 90,000 - 130,000; Full time

Job summary

Orion Pharma in Cambridge, UK, seeks a highly motivated scientist to join the Antibody Discovery & Engineering group. You will lead engineering efforts across antibody formats and guide a Molecular Biology team to drive platform advancement and manufacturing of antibody libraries.

The role involves collaboration with computational sciences, protein sciences and discovery biology to shape experimental design and ensure highquality deliverables for clinical development.

Qualifications

• PhD in protein engineering or related field with industrial experience.
• Experience leading antibody design and development projects.
• Strong knowledge of antibody modalities and engineering techniques.
• Proven leadership and collaboration across cross-functional teams.

Responsibilities

• Play a lead role in advancing and optimising the platform and help in the generation of novel antibody libraries.
• Provide scientific oversight of antibody architecture and format selection, including conventional antibodies, fragments, bispecific and multispecific antibodies, Fc-engineered molecules, conjugation-ready formats and other fit-for-purpose protein constructs.
• Collaborate cross-functionally with the computational sciences, protein sciences and discovery biology teams to integrate experimental design.
• Lead a small Molecular Biology team and understand and be up to date on the state of the art techniques, innovation and instrumentation in this area
• Mentor junior scientists and guide technical development, fostering innovation and best practices within the team.
• Stay at the forefront of antibody engineering technologies and scientific trends; identify and evaluate novel methods for potential adoption.
• Act as the primary point of contact for antibody and novel-format requests from research project teams, clarifying the biological question, intended use, target product profile, required format, quality attributes, timelines and decision criteria.
• Supervise generation of required reagents by enabling production either internally or externally with the CROs, technology providers and other external partners, including technical scoping, statements of work, material and data transfer, performance monitoring, troubleshooting and quality review.
• Maintain transparent request tracking, documentation and reporting, including scope, status, decisions, risks, changes, data packages, material inventories and handover information.

Skills

Antibody engineering

Molecular biology

Leadership

NGS

Automation

Biopharma

Education

PhD in protein engineering

MSc in related field

Job description

Orion Pharma in Cambridge, UK, seeks a highly motivated scientist to join the Antibody Discovery & Engineering group. You will lead engineering efforts across antibody formats and guide a Molecular Biology team to drive platform advancement and manufacturing of antibody libraries.

The role involves collaboration with computational sciences, protein sciences and discovery biology to shape experimental design and ensure highquality deliverables for clinical development.