Senior Scientist: Antibody Characterisation & Development

Northreach; Greater London; On-site; GBP 60,000 - 90,000; Full time

Job summary

Northreach is seeking a Senior Scientist to lead antibody characterisation and develop strategies across discovery and preclinical programmes. You will design and implement assays (SPR,BIAcore, BLI, ELISA), interpret complex datasets and guide candidate selection for progression to the next development stage, with collaboration across internal teams and external CROs.

The role combines hands-on experiments with scientific leadership, mentoring junior scientists and shaping developability

Qualifications

• PhD or equivalent industry experience in biochemistry/biophysics or related field.
• Strong industry experience in therapeutic monoclonal antibody discovery, characterisation or biologics development.
• Hands-on expertise in SPR/Biacore, BLI and/or ELISA including assay development and troubleshooting.
• Broad understanding of antibody binding, affinity, kinetics, specificity and developability.
• Experience interpreting characterisation data to support optimisation and candidate selection.
• Experience managing scientific workstreams and collaborating with CROs or external partners.
• Strong experimental design, data analysis and scientific communication skills.
• Proactive, collaborative approach with ownership of scientific activities.

Responsibilities

• Design, develop and optimise antibody characterisation assays (SPR/Biacore, BLI, ELISA).
• Assess affinity, kinetics, specificity and functional characteristics to support candidate selection.
• Generate and interpret data, identify liabilities and recommend next steps.
• Lead scientific workstreams and coordinate activities across teams and external partners.
• Manage CRO relationships: review protocols, plans and reports.
• Collaborate with discovery and computational teams to support optimisation and development strategies.
• Troubleshoot challenges to ensure high-quality, reproducible results; communicate findings to stakeholders.

Skills

Antibody characterisation

SPR

Biacore

BLI

ELISA

Data analysis

Experimental design

Mentoring

External collaboration

Education

PhD in Biochemistry/Biophysics

Tools

HPLC

SEC

LC-MS

DSC

Job description

Northreach is seeking a Senior Scientist to lead antibody characterisation and develop strategies across discovery and preclinical programmes. You will design and implement assays (SPR,BIAcore, BLI, ELISA), interpret complex datasets and guide candidate selection for progression to the next development stage, with collaboration across internal teams and external CROs.

The role combines hands-on experiments with scientific leadership, mentoring junior scientists and shaping developability