Postdoctoral Researcher in Genomics and Genome Editing

Economics Network; Oxford; Hybrid; GBP 39,000 - 48,000; Full time

Job summary

Economics Network invites applications for a Postdoctoral Researcher in Oxford to develop cutting-edge genome editing methods as part of the MRC Centre for Therapeutic Genomics. The role focuses on building a bespoke platform for treating rare disease using genome editing technologies.

You will plan and carry out laboratory research, generate high-quality data for publication, and present findings at regular meetings, reporting to the group head.

Qualifications

• PhD (or submitted) in Haematology, Genome Editing or related field with relevant experience.
• Experience with complex genome editing and single cell genomics.
• Experience with murine transplantation models and flow cytometry.

Responsibilities

• Plan and perform laboratory research on genome editing projects.
• Generate high-quality data and contribute to publications.
• Present data and ideas at regular meetings.
• Report progress to the Group Head; work independently and in a team.

Skills

Genome editing

Single cell genomics

Flow cytometry

Murine transplantation models

CRISPR gRNA cloning

Education

PhD in Haematology or Genome Editing

Tools

CIRCLE-seq

GUIDE-seq

CRISPR base editing

Prime editing

Job description

Location:Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford

Applications are invited for a Postdoctoral Researcher position to work with Professor James Davies and Professor Ronjon Chakraverty. This is an exciting opportunity to work on developing cutting-edge genome editing methods as part of the new MRC Centre of Research Excellence (CoRE) in Therapeutic Genomics. The main focus of the work is to develop a bespoke platform for using genome editing to treat rare disease.

You will be responsible for planning and carrying out laboratory research, generating high quality data and writing up findings for publication. You will also need to present data and ideas at regular meetings, and to report and communicate on a regular basis with the Group Head. Working both independently and as part of a team, it is essential that you are able to communicate effectively.

You will have a PhD (or submitted thesis) in Haematology, Genome Editing or a related discipline, together with relevant experience. Experience of conducting complex genome editing and single cell genomics experiments, as well as designing and carrying out experiments with murine models of transplantation will be essential. Experience of purification of cells from blood and bone marrow using flow cytometry and cell sorting is also required together with experience of advanced genome editing including cloning of CRISPR gRNAs for custom screens, base editing (including alternative specificity Cas enzymes) and prime editing. Experience of off-target assays such as CIRCLE-seq and GUIDE-seq and a strong publication record are desirable.

This position is available fixed term for 12 months, funded by the Medical Research Council.

Closing date for this position is 12.00 noon on 5 October 2026.

£39,424 to £47,779 per annum. Grade 7