Post-Doctoral Research Scientist

Corehr; Oxford; On-site; GBP 36,000 - 42,000; Full time

Job summary

The University of Oxford's Radcliffe Department of Medicine invites applications for a post-doctoral Research Scientist in gene therapy, based at the John Radcliffe Hospital, Oxford. You will join the Gene Medicine Research Group to develop Lentiviral derived nanoparticles (LVNPs) aimed at treating rare diseases and to optimise scalable production and purification strategies.

Applicants should hold (or be completing) a PhD/DPhil in gene therapy or a closely related field, with experience in gene

Qualifications

• PhD or in-progress in gene therapy or a closely related field.
• Experience in gene delivery, cell culture and analytical techniques.
• Home Office licence with in vivo gene delivery experience would be advantageous.

Responsibilities

• Optimise LVNP production at scale, including purification and concentration testing.
• Collaborate in a multi-disciplinary team within the Gene Medicine Research Group.
• Contribute to translational research projects and ensure high standards of data quality.

Skills

Gene therapy

Lentiviral vectors

Gene delivery

Mammalian cell culture

Flow cytometry

ddPCR

Vector production

Chromatography

Education

PhD in gene therapy/gene editing

Tools

ddPCR

Chromatography

Vector production

Job description

UK date and time: 24-September-2026 13:01

Radcliffe Department of Medicine (RDM), Nuffield Division of Clinical Laboratory Sciences (NDCLS), John Radcliffe Hospital, Headington, Oxford OX3 9DU

We are seeking an enthusiastic post-doctoral research scientist in gene therapy at the University of Oxford, based at the John Radcliffe Hospital, to join the Gene Medicine Research Group, directed by Professors Deborah Gill and Steve Hyde.

You will be part of a multi-disciplinary team developing Lentiviral derived nanoparticles (LVNPs) to treat rare diseases and will be keen to participate in translational research. You will have responsibility for optimising processes required to produce LVNPs at scale including testing strategies for purification and concentration.

You will hold (or be in the process of completing) a PhD/DPhil in gene therapy/gene editing, or a closely related field. Relevant laboratory experience in gene delivery, mammalian cell culture, flow cytometry, ddPCR, vector production and chromatography is essential, along with excellent communication and inter-personal skills required for integrated team working. A Home Office Licence with experience in gene delivery in vivo would be an advantage.

The position is available immediately and is funded by the Edinburgh BioEngineering Hub award for 6 months.

The closing date for applications is 12 noon on 30 September 2026

Please quote reference number 188892 in all correspondence.

Committed to equality and valuing diversity.