Research Facility Scientist (Transgenics and Genome Engineering)

Corehr; Oxford; On-site; GBP 32,000 - 46,000; Full time

Job summary

We are seeking a Research Facility Scientist to join the MRC Weatherall Institute of Molecular Medicine Genome Engineering, Transgenics and Virus Production Facility in Oxford. You will design, generate and validate genetically modified models using CRISPR/Cas9, collaborating with researchers to meet experimental needs.

You will manage multiple projects, perform complex workflows, and provide technical guidance while delivering high-quality results in a supportive team environment.

Qualifications

• Degree in Biological Sciences, Molecular Biology, Genetics or closely related discipline.
• Significant experience with CRISPR/Cas9 technology and cell culture.
• Experience with generating and validating genetically modified models.

Responsibilities

• Design, generate and validate genetically modified models.
• Collaborate with researchers to understand experimental requirements and develop genome-engineering strategies.
• Lead technically complex workflows from design to validation and deliver high-quality results.
• Provide technical advice and communicate progress clearly to facility users.

Skills

CRISPR/Cas9

Cell culture

Genome engineering

Experimental design

Education

Biological Sciences or related degree

Tools

CRISPR/Cas9

iPSC/mESC cell culture

Job description

UK date and time: 24-September-2026 13:03

Research Facility Scientist (Transgenics and Genome Engineering)

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, Genome Engineering Services Facility, John Radcliffe Hospital, Headington, Oxford, OX3 9DS

An underfill at Grade 6 will be considered with amended duties and a 12-month development plan and mentoring put in place for the successful candidate.

*This vacancy is being re-advertised. Previous applicants need not apply*

We have an exciting opportunity to join the Institute as a Research Facility Scientist within the MRC WIMM Genome Engineering, Transgenics and Virus Production Facility.

The MRC WIMM Genome Engineering, Transgenics and Virus Production Facility is a specialist core Facility providing expertise in the design, generation and validation of genetically modified model systems. Working with research groups across the Institute, we combine molecular and cellular biology with state-of-the-art genome engineering and transgenic technologies to produce high-quality, validated reagents and models that enable cutting-edge biomedical research.

Our work encompasses CRISPR-based genome engineering, generation of genetically modified cell lines and mouse models, molecular validation, mouse embryonic stem cell technologies, cryopreservation and rederivation. We work closely with researchers from initial experimental design through to delivery of validated, ready-to-use models.

About the Role

As a Research Facility Scientist, you will join an experienced specialist team and contribute to all aspects of the design, generation and validation of genetically modified models.

You will work closely with researchers to understand their experimental requirements and help develop appropriate genome-engineering strategies. You will take responsibility for technically complex laboratory workflows, from molecular design and reagent generation through to genome editing, screening and molecular validation.

An important part of the role will be working collaboratively with Facility users. You will discuss project requirements with researchers, provide technical advice and communicate experimental progress and results clearly. You will manage multiple projects at different stages of delivery and work closely with other members of the facility to ensure an efficient and high-quality service.

About You

You will hold a degree in Biological Sciences, Molecular Biology, Genetics or a closely related discipline and have substantial relevant laboratory experience. Experience in core molecular biology techniques, including significant experience in CRISPR/Cas9 technology and cell culture techniques including iPSC, mESC and other cell lines, will be essential.

You will be confident in planning and carrying out technically complex laboratory work and will have a systematic approach to experimental design, troubleshooting and interpretation of results. You will be able to work independently, exercise sound scientific judgement and manage multiple projects and competing priorities while maintaining consistently

high standards of accuracy and reproducibility.

Excellent interpersonal and communication skills and being comfortable working collaboratively with researchers from a wide range of scientific backgrounds will be required. You will be able to explain technical information clearly, discuss experimental options and limitations, and provide constructive scientific advice.

You will be proactive, organised and collaborative, with a strong commitment to delivering a high-quality research service.

Contract Type

This is a full-time (37.5 hours per week) fixed-term position for 3 years.

The closing date for this position is 12 noon on Wednesday 14 October 2026. Interviews will be held on Tuesday 3 November 2026.