Research Facility Scientist (Transgenics and Genome Engineering)

University of Oxford; Oxford; On-site; GBP 36,000 - 48,000; Full time

Job summary

The University of Oxford's Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine invites applications for a Research Facility Scientist in the Genome Engineering, Transgenics and Virus Production Facility. You will join a specialist team delivering genetically modified models and reagents to researchers across the Institute.

You will design, generate and validate genome-modified cell lines and mouse models using CRISPR and related technologies, manage multiple

Qualifications

• Substantial relevant laboratory experience.
• Broad practical expertise in molecular and cellular biology.
• Experience applying genome-engineering approaches to generation and validation of genetically modified model systems.
• Confident in planning and carrying out technically complex laboratory work.
• Systematic approach to experimental design, troubleshooting and interpretation of results.
• Excellent interpersonal and communication skills; able to explain technical information clearly.

Responsibilities

• Design, generation and validation of genetically modified models across research groups.
• Collaborate with researchers to understand experimental requirements and develop genome-engineering strategies.
• Take responsibility for technically complex laboratory workflows from molecular design to genome editing, screening and validation.
• Work collaboratively with Facility users and discuss project requirements; provide technical advice and progress updates.
• Manage multiple projects at different stages to ensure efficient, high-quality service.
• Maintain high standards of accuracy and reproducibility in all work.

Skills

CRISPR genome engineering

Genome editing

Cell culture

Molecular biology

Experimental design

Education

Degree in Biological Sciences, Molecular Biology, Genetics or closely related discipline

Job description

Radcliffe Department of Medicine, MRC Weatherall Institute of Molecular Medicine, Genome Engineering Services Facility, John Radcliffe Hospital, Headington, Oxford, OX3 9DS

This vacancy is being re-advertised. Previous applicants need not apply.

We have an exciting opportunity to join the Institute as a Research Facility Scientist within the MRC WIMM Genome Engineering, Transgenics and Virus Production Facility. The MRC WIMM Genome Engineering, Transgenics and Virus Production Facility is a specialist core Facility providing expertise in the design, generation and validation of genetically modified model systems. Working with research groups across the Institute, we combine molecular and cellular biology with state-of-the-art genome engineering and transgenic technologies to produce high-quality, validated reagents and models that enable cutting-edge biomedical research. Our work encompasses CRISPR-based genome engineering, generation of genetically modified cell lines and mouse models, molecular validation, mouse embryonic stem cell technologies, cryopreservation and rederivation. We work closely with researchers from initial experimental design through to delivery of validated, ready-to-use models. As a Research Facility Scientist, you will join an experienced specialist team and contribute to all aspects of the design, generation and validation of genetically modified models. You will work closely with researchers to understand their experimental requirements and help develop appropriate genome-engineering strategies. You will take responsibility for technically complex laboratory workflows, from molecular design and reagent generation through to genome editing, screening and molecular validation. An important part of the role will be working collaboratively with Facility users. You will discuss project requirements with researchers, provide technical advice and communicate experimental progress and results clearly. You will manage multiple projects at different stages of delivery and work closely with other members of the facility to ensure an efficient and high-quality service.

You will hold a degree in Biological Sciences, Molecular Biology, Genetics or a closely related discipline and have substantial relevant laboratory experience. You will have broad practical expertise in molecular and cellular biology, together with experience applying genome-engineering approaches to the generation and validation of genetically modified model systems. You will be confident in planning and carrying out technically complex laboratory work and will have a systematic approach to experimental design, troubleshooting and interpretation of results. You will be able to work independently, exercise sound scientific judgement and manage multiple projects and competing priorities while maintaining consistently high standards of accuracy and reproducibility. You will have excellent interpersonal and communication skills and be comfortable working collaboratively with researchers from a wide range of scientific backgrounds. You will be able to explain technical information clearly, discuss experimental options and limitations, and provide constructive scientific advice. You will be proactive, organised and collaborative, with a strong commitment to delivering a high-quality research service.