Method Development Lead

Nexus Life Sciences; Bournemouth; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Competitive salary up to £60,000

Leadership opportunity

Professional development

Collaborative work culture

Cutting-edge bioanalytical projects

Job summary

Nexus Life Sciences is seeking an MS Method Development Lead in the United Kingdom to drive development and validation of LCMSMS bioanalytical methods under GxP standards. The role combines technical expertise with leadership of the Method Development & Validation team.

You will optimise extraction techniques, chromatography methods, and LC columns, ensure GLP compliance, and support regulatory submissions. A strong background in HPLC/UPLC/LCMSMS and problem-solving is essential.

Qualifications

• Degree in Biochemistry, Biomedical Science, or a related field.

Responsibilities

• Lead method development and validation as a subject matter expert.
• Optimise extraction techniques, chromatography methods, and LC columns.
• Manage and mentor the Method Development & Validation team.
• Ensure GLP compliance and follow SOPs and international guidelines.
• Troubleshoot analytical methods and identify improvements.
• Oversee cost-effective laboratory operations and consumables.
• Write and approve Methods of Analysis and transfer validated methods.
• Support regulatory submissions and respond to regulatory queries.
• Conduct investigations, implement CAPAs, and drive continuous improvement.
• Prepare and adhere to GLP SOPs; lead team meetings and staff development.

Skills

GxP leadership

LCMSMS expertise

HPLC/UPLC

Method development

Regulatory compliance

Problem solving

Communication

Leadership

Education

Degree in Biochemistry or Biomedical Science

Tools

Empower

MassLynx

Minitab

Job description

About the Role

We are seeking a highly skilled MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards.

This role combines technical expertise and team leadership.

Responsibilities

• Key duties include:
• Leading method development and validation as a subject matter expert.
• Optimising analytical extraction techniques, chromatography methods, and LC columns.
• Managing and mentoring the Method Development & Validation team.
• Ensuring compliance with GLP, SOPs, and international guidelines.
• Troubleshooting analytical methods and recommending improvements.
• Overseeing cost-effective laboratory operations and consumable spend.
• Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
• Supporting regulatory submissions and resolving regulatory queries.
• Conducting investigations, implementing CAPAs, and driving continuous improvement.
• Preparing, reviewing, and ensuring adherence to GLP SOPs.
• Leading team meetings and staff development sessions.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.

Required Skills

• 4+ years in a GxP laboratory (2+ years in management).
• Expertise in HPLC, UPLC, LCMSMS, and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction techniques.
• Understanding of regulatory and GLP requirements.
• Strong communication, organisational, and leadership skills.

Preferred Skills

• Experience with Design of Experiments (DOE) for method optimisation.
• Proficiency in Minitab/statistical software.
• Experience with Empower and Mass Lynx data systems.
• GC experience and familiarity with regulatory inspections.

Pay range and compensation package

• Competitive salary up to £60,000.
• Leadership opportunity in a cutting-edge lab environment.
• Professional development and training opportunities.
• Supportive, collaborative work culture.
• Chance to contribute to innovative bioanalytical projects.