Lead Scientist, Antibody Discovery & Engineering

Orion Corporation; Cambridge; On-site; GBP 70,000 - 100,000; Full time

Job summary

Orion Biologics is seeking a highly motivated scientist to join the Antibody Discovery & Engineering group in Cambridge, UK, to lead program efforts on therapeutic antibody platforms.

You will oversee platform development, guide antibody architecture decisions (including bispecific/multispecific formats), mentor junior scientists, and collaborate with cross‑functional teams to deliver assets through discovery to preclinical stages.

Qualifications

• Ph.D. in protein engineering, molecular biology or related with 3+ years industrial experience, or MSc with 5+ years in antibody discovery.
• Broad expertise in antibody engineering and understanding of the antibody structure/function relationship.
• Experience with engineered/optimized antibodies and multispecific formats designed for diverse mechanisms of action.

Responsibilities

• Play a lead role in advancing and optimising the platform and help in the generation of novel antibody libraries.
• Provide scientific oversight of antibody architecture and format selection, including conventional antibodies, fragments, bispecific and multispecific antibodies, Fc-engineered molecules, conjugation-ready formats and other fit-for-purpose protein constructs.
• Collaborate cross-functionally with the computational sciences, protein sciences and discovery biology teams to integrate experimental design.
• Lead a small Molecular Biology team and mentor junior scientists and guide technical development.
• Stay at the forefront of antibody engineering technologies and identify novel methods for potential adoption.
• Act as the primary point of contact for antibody and novel-format requests from research project teams and manage external CROs.

Skills

Antibody engineering

Team leadership

Molecular biology

NGS data analysis

Automation experience

Education

PhD in protein engineering or molecular biology

Tools

NGS platforms

Protein expression & purification

Biophysical characterization

Job description

Orion Biologics is seeking a highly motivated scientist to join the Antibody Discovery & Engineering group in Cambridge, UK, to lead program efforts on therapeutic antibody platforms.

You will oversee platform development, guide antibody architecture decisions (including bispecific/multispecific formats), mentor junior scientists, and collaborate with cross‑functional teams to deliver assets through discovery to preclinical stages.