LC-MS/MS Method Development Lead

Nexus Life Sciences

Bradford

On-site

GBP 36,000 - 60,000

Full time

5 days ago

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Job summary

Nexus Life Sciences in Bradford, UK, is seeking an MS Method Development Lead to drive the development and validation of LCMSMS bioanalytical methods under GxP standards. This role combines technical expertise with team leadership.

You will lead method development, optimise extraction and chromatography, mentor the Method Development & Validation team, ensure GLP compliance, support regulatory submissions, and drive continuous improvement in a cutting-edge laboratory environment.

Qualifications

Degree in Biochemistry, Biomedical Science, or related field.
4+ years in a GxP laboratory with at least 2 years in a supervisory/managerial role.
Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
Proficiency in method development, optimisation and validation.
Strong problem-solving and troubleshooting capabilities.
Knowledge of protein precipitation, SPE, and Liquid-Liquid extraction.
Understanding of regulatory and GLP requirements.
Strong communication, organisational and leadership skills.

Responsibilities

Leading method development and validation as a subject matter expert.
Optimising analytical extraction techniques, chromatography methods, and LC columns.
Managing and mentoring the Method Development & Validation team.
Ensuring compliance with GLP, SOPs, and international guidelines.
Troubleshooting analytical methods and recommending improvements.
Overseeing cost-effective laboratory operations and consumable spend.
Writing and approving Methods of Analysis and transferring validated methods to analytical teams.
Supporting regulatory submissions and resolving regulatory queries.
Conducting investigations, implementing CAPAs, and driving continuous improvement.
Preparing, reviewing, and ensuring adherence to GLP SOPs.
Leading team meetings and staff development sessions.