Lead LC-MS/MS Method Development (GxP)

Nexus Life Sciences; Warrington; On-site; GBP 54,000 - 66,000; Full time

Benefits offered by this job

Competitive salary up to £60,000

Leadership opportunity

Professional development

Collaborative work culture

Job summary

Nexus Life Sciences in Warrington seeks a highly skilled MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards. The role blends technical leadership with people management.

You will lead method development, optimize chromatographic methods, mentor the MD&V team, and ensure GLP/SOP compliance while supporting regulatory submissions and continuous improvement.

Qualifications

• Degree in Biochemistry, Biomedical Science, or related field.
• 4+ years in a GxP laboratory with 2+ years in management.
• Expertise in HPLC, UPLC, LCMSMS and chromatography data systems.
• Proficiency in method development, optimisation, and validation.
• Strong problem-solving and troubleshooting capabilities.
• Knowledge of protein precipitation, SPE, and liquid–liquid extraction.
• Understanding of regulatory and GLP requirements.

Responsibilities

• Lead method development and validation as SME.
• Optimise extraction techniques and chromatographic methods.
• Mentor the Method Development & Validation team.
• Ensure GLP, SOP, and regulatory compliance.
• Troubleshoot methods and implement improvements.
• Oversee cost-effective lab operations and consumables.
• Write and approve Methods of Analysis; transfer to teams.
• Support regulatory submissions and handle inquiries.
• Drive CAPAs and continuous improvement.
• Prepare and ensure GLP SOP adherence.
• Lead team meetings and staff development.

Skills

GxP leadership

HPLC/UPLC

LCMSMS

Chromatography data systems

Method development & validation

Regulatory compliance

Problem solving

Communication & leadership

Education

Biochemistry/Bio/related degree

Tools

Empower

MassLynx

Minitab

Job description

Nexus Life Sciences in Warrington seeks a highly skilled MS Method Development Lead to drive LCMSMS bioanalytical method development and validation under GxP standards. The role blends technical leadership with people management.

You will lead method development, optimize chromatographic methods, mentor the MD&V team, and ensure GLP/SOP compliance while supporting regulatory submissions and continuous improvement.