Scientist (m/w/d)

Proteome Sciences R&D GmbH & Co KG; Frankfurt; Vor Ort; EUR 70.000 - 110.000; Vollzeit

Zusammenfassung

Proteome Sciences R&D GmbH & Co. KG based in Frankfurt am Main is seeking an exceptionally qualified Senior Mass Spectrometry Specialist to join its Mass Spectrometry team.

The role focuses on operating and optimizing LC–MS systems, developing quantitative proteomics workflows, and delivering high-quality data for client projects and internal R&D. Ideal candidates will hold a PhD with 2–5 years of industry or CRO experience, and possess strong expertise in proteomics software and quantitative MS

Qualifikationen

• PhD with 2–5 years of professional experience, preferably in industry or CRO.
• Strong hands-on experience with LC-MS/MS and proteomics workflows.
• Proficiency in quantitative MS techniques (e.g., TMT, DIA, DDA, PRM).
• Excellent technical documentation and client reporting skills.
• Fluent written and spoken English.

Aufgaben

• Operate, calibrate, maintain, and troubleshoot mass spectrometry and nano-LC equipment.
• Develop and optimize quantitative LC-MS methods for client projects and R&D.
• Oversee project execution, capacity planning, and cross-team coordination.
• Quality control of MS raw data and data processing with proteomics software.
• Contribute to client communications, proposals, and technical reports.
• Provide guidance and training to laboratory personnel.
• Ensure compliance with ISO9001:2015 and GxP requirements.

Kenntnisse

Mass spectrometry

LC–MS methods

Project coordination

Documentation

English communication

Ausbildung

PhD in proteomics or related

Tools

Proteome Discoverer

DIA-NN

Skyline

Nano LC MS instrumentation

Jobbeschreibung

Proteome Sciences plc (www.proteomics.com) is a global leader in applied proteomics with scientific operations based in Frankfurt am Main (Germany) and San Diego (CA, USA). We partner with innovative companies and academic research groups and offer high sensitivity, proprietary technologies for protein and peptide biomarker discovery, validation and assay development.

We are looking for an exceptionally qualified and highly motivated

Senior Mass Spectrometry Specialist (m/f/d)

to join our Mass Spectrometry team based on our ISO9001:2015 certified facility at Proteome Sciences R&D GmbH &Co. KG in Frankfurt am Main.

• Independent operation, calibration, routine maintenance, and advanced troubleshooting of mass spectrometry and liquid chromatography (nano-LC) equipment.
• Development, optimization, and execution of quantitative LC-MS methods (including TMT, DIA, DDA, and targeted studies) for client projects and R&D.
• Technical oversight of project execution, capacity planning, and resource management in interaction with other teams to ensure timely delivery within budget.
• Diligent tracking and initial quality control of MS raw data in close interaction with the Bioinformatics and wet-lab team.
• Technical consulting and contribution to client communications, including project proposals, data presentations, and technical reports.
• Guidance and technical support for laboratory personnel to maintain high operational standards and best laboratory practices.
• Ensuring strict compliance of MS procedures with ISO9001:2015 and GCLP requirements.

• Ph.D. with 2-5 years of professional, preferably industrial or CRO background, operating LC-MS systems in a proteomics environment.
• Strong hands‑on experience and deep technical knowledge of nano LC and MS applied to peptides and proteins, including advanced instrument operation and troubleshooting.
• Solid proficiency with quantitative MS techniques (e.g., TMT, DIA, DDA, PRM).
• Expert-level knowledge of proteomic data processing software (e.g., Proteome Discoverer, DIA-NN, Skyline)
• Robust project coordination, time management, and organizational skills.
• Excellent technical documentation skills and readiness to contribute to client reports and presentations.
• Clear and proficient communication in written and spoken English.

Advantageous for the role:

• First exposure to technical leadership, mentoring junior team members, or managing project workflows.
• Working knowledge or fluency in German.
• Familiarity with quality management requirements (ISO 9001, GxP).
• Practical knowledge of programming and/or scripting tools such as Python and R.

• A high-impact technical role at a market leading company in applied proteomics and biomarker discovery.
• Challenging projects in collaboration with international pharma, biotech, and academic leaders.
• A friendly, welcoming working atmosphere and support for professional development.