Scientist (m/f/d) (Protein Biomarker Assay Development and Validation) at Centogene GmbH

CENTOGENE GmbH; Rostock; On-site; EUR 45,000 - 65,000; Full time

Benefits offered by this job

Language courses support

International team collaboration

Job summary

CENTOGENE GmbH in Rostock, Germany, is seeking a Scientist (m/f/d) in Protein Biomarker Assay Development and Validation to advance ELISA and other immunoassays for diagnostic use. This full-time, on-site role offers opportunities for career growth within a translational research environment.

You will design and validate protein assays, build scalable workflows, document results under GLP/GCLP, and collaborate across R&D and QA.

Qualifications

• PhD in Biochemistry, Molecular Biology or related field.
• Hands-on experience developing/validating protein assays.
• GxP environments knowledge (GLP/GCLP).
• Data analysis with Excel, GraphPad Prism; R or Python experience.
• Knowledge of IVDR and GDPR is advantageous.

Responsibilities

• Design, plan and execute development and validation studies for protein-based biomarker assays (ELISA, immunoassays, PEA, functional assays).
• Build robust assay workflows and support transfer to new technologies.
• Write validation documentation per GLP/GCLP standards.
• Ensure diagnostic quality and regulatory compliance.
• Develop assays suitable for in-house IVDR-compliant use; support clinical studies.
• Analyze data with Excel, GraphPad Prism, R or Python; present findings.
• Collaborate cross-functionally with R&D, QA and external partners.

Skills

Biochemistry

Molecular Biology

Data analysis

GLP/GCLP experience

R

Python

Excel

GraphPad Prism

qPCR

NGS

Education

PhD in Biochemistry or Molecular Biology

Tools

GraphPad Prism

R

Python

Excel

qPCR

NGS

Job description

Scientist (m/f/d) (Protein Biomarker Assay Development and Validation)

Centogene GmbH at Rostock, MV, DE.

Full time on site position offers great opportunities for career growth.

Your Responsibilities

• Design, plan and execute development and validation studies for protein-based biomarker assays, e.g., ELISA and other immunoassays, proximity extension assays (PEA) and functional assays
• Build robust, scalable and transferable assay workflows, and support assay transfer and the implementation of new technologies
• Write high-quality validation documentation in line with internal and regulatory standards (GLP/GCLP)
• Diagnostic quality and compliance
• Develop and validate assays to quality standards suitable for diagnostic use, including potential in-house IVD assays in line with applicable EU regulations (e.g., IVDR)
• Support clinical studies, from assay qualification to sample analysis and reporting
• Handle patient samples and data responsibly and in compliance with EU data protection law (GDPR) and internal policies
• Data analysis
• Analyze and interpret experimental data with Excel, GraphPad Prism and R or Python, applying sound statistics to reach clear biological conclusions that guide project decisions
• Use AI tools, including large language models (LLMs), responsibly for data analysis, literature research and documentation, in line with data protection and quality requirements
• Where relevant, work with structured datasets and databases
• Communication and collaboration
• Work cross-functionally with R&D, Quality Assurance and external partners
• Contribute to SOPs, reports, manuscripts and publications
• Present your results internally, to partners and at scientific conferences

Your profile

• Required PhD in Biochemistry, Molecular Biology or a related field
• Strong background in protein-focused biochemistry
• Hands-on laboratory experience in developing and validating protein assays, e.g., immunoassays
• Familiarity with working in GLP/GCLP environments
• Confident data analysis with Excel and GraphPad Prism, and working experience with R and/or Python
• Fluent English, written and spoken German at A2 level or higher, and willingness to improve towards B1
• A plus Postdoctoral or industry experience
• Experience with proximity extension assays and their readouts, qPCR and/or next-generation sequencing (NGS)
• Knowledge of diagnostic regulations (e.g., IVDR) and data protection requirements (GDPR)
• Experience with cellular models, ideally in a neurological context
• Experience with, or strong interest in, the responsible use of LLMs and other AI tools in scientific work
• Exposure to SQL or database environments

How you work

• You plan, run and document your own studies in a structured and reliable way
• You communicate results clearly, in writing and in presentations
• You bring your own ideas, question existing approaches and want to help shape how the team works

Why us?

• Translational research with direct relevance for patients with rare and neurodegenerative diseases
• An international, multidisciplinary team and close collaboration with pharmaceutical partners
• Room to take ownership of your projects, help build the team and keep learning
• Support with German language courses
• A 12-month contract with the possibility of transitioning to a permanent position

About us

With employees from over 50 nations, CENTOGENE is a truly international company with offices is in Rostock, Berlin, Delhi, Boston, Valencia, Belgrade, and São Paulo. We were born to help diagnostic patients with rare disease and today we evolved to help patients of all clinical specialties to make bold progress with guided solutions for physicians, their patients and pharma partners.