Scientist - Computational Biology [m/f/d]

Resolve Biosciences; Monheim; On-site; EUR 50,000 - 70,000; Full time

Job summary

A dynamic life science company in Monheim is seeking a passionate Scientist - Computational Biology to join their Assay Development team. The successful candidate will analyze high-dimensional spatial single-cell data in immuno-oncology contexts and work collaboratively with various teams. Candidates with a PhD in relevant fields and experience with tools like Seurat or Scanpy are encouraged to apply. This full-time position offers the opportunity to contribute to vital cancer treatment research.

Qualifications

• 3+ years of relevant experience in computational biology or bioinformatics.
• Extensive experience analyzing high-dimensional single-cell data.
• Proficiency in statistical methods applied to biological data.

Responsibilities

• Apply tools for computational analysis of multi-omic datasets.
• Design and evaluate targeted gene panels.
• Collaborate with cross-functional teams.

Skills

High-dimensional data analysis

Statistical analysis

Teamwork

Communication skills

Software tools proficiency (R/Python)

Education

PhD in biology, bioinformatics, or a related field

Tools

Seurat

Scanpy

Snakemake

Nextflow

Job description

Scientist - Computational Biology [m/f/d]

Join to apply for the Scientist - Computational Biology [m/f/d] role at Resolve Biosciences.

Your mission

Improve the future of cancer treatment with us - determined, courageous and as a team! At Resolve Biosciences, we are working to better understand complex biological processes – with the aim of enabling new therapeutic approaches. We need people who think boldly, take responsibility and enjoy learning. We are looking to hire a passionate Scientist - Computational Biology [m/f/d] to join our Assay Development team. By working closely with biologists and biomedical experts, you will be responsible for the computational analysis of high-dimensional spatial single-cell data, with a strong focus on immuno-oncology and targeted gene panel design. This is a full-time position based at our company headquarters in Monheim am Rhein, Germany, where you will collaborate closely with the Application Development, Molecular Biology, and Data Science teams.

Key Responsibilities

• Apply software tools and pipelines for computational downstream analysis of Molecular Cartography spatial multi-omic datasets.
• Design and evaluate targeted gene panels for performance and accuracy.
• Derive biological insights from high-dimensional single-cell data (imaging- and sequencing-based), such as cell type identification, differential expression, cellular neighborhoods, and cell-cell communication.
• Assess the impact of technical variables (e.g., optical crowding, cell segmentation) on data analysis results.
• Use solid statistical methods to evaluate data quality, identify patterns, and draw meaningful biological conclusions.
• Collaborate with cross-functional teams and gather requirements from team members and other project teams.
• Train and support internal users in the use of data analysis tools and pipelines when necessary.
• Collaborate effectively to achieve shared project goals and meet deadlines.
• Take ownership of personal work planning in alignment with agreed objectives.

Your profile

• PhD in biology, bioinformatics, or a related field, with 3+ years of relevant experience.
• Extensive experience analyzing high-dimensional single-cell data (e.g., scRNA‑seq, spatial transcriptomics) using state‑of‑the‑art tools such as Seurat or Scanpy.
• Experience in computational single‑cell analysis in oncology and/or systems immunology is preferred.
• Strong foundational understanding of statistics and its application to biological data.
• Proficiency in R or Python is required; proficiency in both is preferred.
• Experience with fluorescence microscopy, image analysis, and associated software tools is a plus.
• Familiarity with workflow tools like Snakemake or Nextflow is beneficial.
• Experience in experimental/study design for harmonized analysis across multiple experiments and large sample sets is a strong asset.
• Exceptional organizational and prioritization skills, with keen attention to scientific detail.
• Structured, team‑oriented mindset, with excellent communication skills and a strong focus on common goals.
• Willingness to travel internationally, if required.

Personal Characteristics

At Resolve Biosciences, we believe that diversity, equity, and inclusion are essential to our success. We welcome applicants of all genders, ethnicities, nationalities, religions, abilities, and backgrounds to apply for our open positions. We are committed to creating a workplace where everyone feels valued, respected, and supported.

Why us?

We are a young, dynamic life science company with a focus on molecular pathology. Since 2020, we have been working on the fields of application and developing our own Molecular Cartography™ technology, which can be used to visualize gene and protein expression in tissue sections at the subcellular level in high spatial resolution. Every individual counts: Our current team of around 60 members work in an interdisciplinary manner, with passion and creativity to advance our goal – because only together we can really make a difference!

Seniority level: Entry level. Employment type: Full-time. Job function: Science and Research. Industries: Business Consulting and Services.