PhD student position

Universitätsmedizin Göttingen; Göttingen; On-site; EUR 20,000 - 27,000; Full time

Benefits offered by this job

PhD-Training

Mentoring durch renommierte Scientist/

Umfassende Infrastruktur

Kinderbetreuung

Job summary

Universitätsmedizin Göttingen sucht eine exzellent motivierte PhD-Studentin bzw. einen PhD-Studenten im Bereich kardiale Optogenetik und Elektrophysiologie, um neue Ansätze zur Behandlung von Herzrhythmusstörungen zu erforschen.

Die Stelle gehört zur Arbeitsgruppe Vegetative Optogenetik am Institut für Kreislaufphysiologie. Sie arbeiten an der Charakterisierung von Channelrhodopsins und optogenetischen Konstrukten in HEK-Zellen und hiPSC-Kardiomyozyten, lernen Patch-Clamp-Techniken, Ca2+-Imaging

Qualifications

• Abgeschlossenes MSc oder gleichwertiger Abschluss in Lebenswissenschaften (Molekularmedizin, Biologie, Chemie, Physik, …).
• Laborerfahrung vorhanden oder erwünscht.
• Eigenständige, verantwortungsbewusste und flexible Arbeitsweise sowie die Fähigkeit, im internationalen Team zu arbeiten.
• Interesse an Grundlagenforschung in Herz-Kreislauf-Forschung, Elektrophysiologie und Optogenetik.

Responsibilities

• Neue Ansätze in der kardialen Optogenetik entwickeln und charakterisieren.
• Rezeptor-Chimere und optogenetische Konstrukte in HEK-Zellen und hiPSC-kardiomyocyten entwerfen, klonieren und testen.
• Patch-Clamp, Ca2+- imaging und MEA-Messungen erlernen.
• Funktionelle Auslese hiPSC-Kardiomyocyten und isometrische Kraftmessungen von Maus- und menschlichen Herzabschnitten.
• Arbeiten in der Arbeitsgruppe Vegetative Optogenetik am Institut für Kreislaufphysiologie.

Skills

Lab work experience

Independent working style

Team collaboration

Interesse an Elektrophysiologie

Interesse an Optogenetik

Education

Master of Science oder äquivalenter Abschluss in Lebenswissenschaften

Job description

Ihre Aufgaben

• Establish and characterize new approaches in cardiac optogenetics
• Design, clone, and test receptor chimeras and optogenetic constructs in HEK cells and hiPSC-derived cardiomyocytes
• Learn patch clamp, Ca2+ imaging and multi-electrode measurements
• Functional readout of hiPSC-derived cardiomyocytes and isometric force measurements of ventricular slices from mice and humans
• Work within the working group vegetative optogenetics at the Institute of Cardiovascular Physiology

Ihre Qualifikationen

• Completed a Master of Science or equivalent in a Life Sciences subject (molecular medicine, biology, chemistry, physics, …)
• Lab work experience
• Independent, responsible, flexible working style and ability to work in an international team
• Interested in basic cardiovascular research, electrophysiology and optogenetics

Wir bieten

• Structured PhD training within GAUSS/GGNB with additional and optional training in the Hertha Sponer College and EKFZ academy for translation
• A stimulating intellectual environment with innovative translational research projects within the interdisciplinary research areas
• Excellent scientific and technical infrastructure
• Mentoring by renowned scientists of the Göttingen Campus and the FOR5807
• A wide range of interesting benefits as a UMG employee (including in-house daycare center, child vacation care, attractive infrastructure; health and sports promoted by excellent company health management)
• Location in a beautiful and historic German university town steeped in tradition, with a campus that includes the University of Göttingen, Max Planck Institutes, German Primate Centre and other local research institutions

Weitere Informationen

We are looking for an excellent and highly motivated PhD student interested in cardiac electrophysiology, including optogenetics and photopharmacology, to understand cardiac arrhythmia better and develop new approaches to treat them. The successful applicant can be assigned to the newly funded FOR5807 consortium to study “Dynamic integration of GPCR signaling to control organ function and animal behavior” and the RTG2824 “Heart & Brain diseases: integrative research across organs”. He/she/it will explore new channelrhodopsins and optoGPCRs developed by us and collaboration partners as well as test new photopharmacological approaches with the aim of further developing cardiac arrhythmia termination.