PhD Student Position (m/f/d) – New Opsins for Optogenetic Therapies

Universitätsmedizin Göttingen I UMG; Göttingen; Vor Ort; EUR 40.000 - 48.000; Teilzeit

Benefits dieser Stelle

65% TV-L E13 position

Collaborative, interdisciplinary lab

State-of-the-art infrastructure

Thesis advisory committee support

Zusammenfassung

Universitätsmedizin Göttingen I UMG seeks a highly motivated PhD student to advance optogenetic actuators for therapeutic applications. The role is embedded in a collaborative environment within Göttingen's leading neuroscience institutes and centers.

Responsibilities include cloning, expressing and characterizing new opsins, developing high-throughput workflows, and supervising students. Strong English communication and a Master’s in a related field are required.

Qualifikationen

• Master’s degree or equivalent in biology/biophysics/biochemistry/neuroscience or related field.
• Practical laboratory experience and basic knowledge of working with biological samples.
• Experience with quantitative data analysis and scientific presentation.
• Proficient communication and writing skills in English.

Aufgaben

• Molecular cloning, genetic modification, and expression of new opsins in mammalian cells and neurons.
• Functional characterization of opsins using molecular biology, assays, fluorescence microscopy, live-cell imaging, and patch-clamp electrophysiology.
• Develop and optimize workflows for higher-throughput screening and data analysis.
• Design new optogenetic tools and subcellular targeting strategies with experimental approaches.
• Present work in lab meetings, thesis committees, and conferences; contribute to publications.
• Supervise Bachelor’s and Master’s students.

Kenntnisse

Analytical skills

Interpersonal skills

Independent thinking

English proficiency

Ausbildung

Master’s degree in biology/biophysics/biochemistry/neuroscience

Jobbeschreibung

We are looking for a highly motivated PhD student with a background in biophysics, biochemistry, molecular biology or neuroscience and a strong interest in protein engineering and optogenetics to advance our efforts in the engineering of light-gated ion channels and the development of a new generation of optogenetic actuators for therapeutic applications.

The Molecular and Cellular Opsin Engineering Lab has recently moved to Göttingen and is part of the highly interdisciplinary and collaborative research environment of the Institute for Auditory Neuroscience and the Else Kröner-Fresenius Center for Optogenetic Therapies. The Center brings together biochemists, neuroscientists, engineers, and medical researchers from different disciplines with the shared goal of advancing optogenetic technologies toward clinical applications.

Göttingen is an internationally renowned center for neuroscience and biomedical research. The Georg-August University and University Medical Center Göttingen, the Max Planck Institute for Multidisciplinary Sciences, the European Neuroscience Institute, and the German Primate Center provide an exceptionally strong and internationally connected research environment. PhD students can additionally benefit from the interdisciplinary training and networking opportunities offered by the Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB).

• Molecular cloning, genetic modification, and expression of new opsins in mammalian cell cultures and primary neurons
• Functional characterization of new opsins using molecular biology, biochemical assays, fluorescence microscopy, live-cell imaging, and whole-cell patch-clamp electrophysiology
• Development and optimization of experimental workflows for higher-throughput screening, including automated data analysis where applicable
• Design of new optogenetic tools and subcellular targeting strategies, together with the development of new experimental approaches
• Regular presentation of your work in lab meetings, thesis advisory committee meetings, and scientific conferences, and contribution to collaborative scientific publications in international peer-reviewed journals
• Opportunity to gain experience in supervising Bachelor’s and Master’s students

• We are looking for an open-minded, enthusiastic, and highly motivated junior researcher with strong analytical and interpersonal skills, the ability to think independently, and a demonstrable interest in basic biological research questions.
• Completed Master’s degree or equivalent in biology, biophysics, physics, biochemistry, molecular medicine, neuroscience, or a related discipline
• Practical laboratory experience and basic knowledge of working with biological samples
• Experience with quantitative data analysis and scientific presentation
• Proficient communication and writing skills in English
• Previous experience in one or more of the following areas would be advantageous but is not required: molecular biology, electrophysiology, live-cell imaging, automated data analysis, or work with photoreceptors and light-sensitive samples. Training in complementary techniques will be provided.

• A 65% position according to TV-L E13, initially funded for three years, with secured funding for an extension of up to two additional years
• A highly collaborative and interdisciplinary research environment with excellent scientific networking opportunities, structured supervision through a thesis advisory committee, and comprehensive scientific training and career-development opportunities
• Access to state-of-the-art infrastructure for molecular biology, imaging, electrophysiology, and optogenetic research
• The opportunity to join a newly established and growing research group, combining the advantages of a small lab — close scientific supervision, direct mentoring, and the freedom to shape your research questions and experimental strategies — with the excellent infrastructure and collaborative environment of a leading international research institution