Sr. Proteomics Scientist - Targeted Protein Degradation (HTS)

Ridgeline Discovery; Basel; Vor Ort; CHF 110.000 - 170.000; Vollzeit

Benefits dieser Stelle

Prime Location

Commuter Benefits

Flexible Working

Christmas Closure

Birthday Day Off

Lunch & Food

Coffee & Connection

Learning & Development

Innovation & Creativity

Our People

Zusammenfassung

The role requires hands-on experience with proteomics, UHPLC and high-resolution MS, and strong collaboration and communication skills in English. Joining the team offers a modern lab, commuter benefits, and opportunities for professional growth.

Qualifikationen

• Master or Bachelor in Biotechnology/Biochemistry/Molecular Biology with 2+ years in proteomics.
• PhD in Biochemistry/Biology/Chemical Biology with 2+ years MS experience preferred.
• Strong data analysis and communication skills in English.
• Experience with UHPLC and high-resolution MS (Orbitrap Astral or timsTOF) is a plus.
• Experience with DIA data analysis and bioinformatics tools (R/Python) is a plus.

Aufgaben

• Collaborate with cell biologists to prepare samples for MS-based screening, operate state-of-the-art high resolution mass spectrometers, analyze and interpret multi-layered data, and present findings to stakeholders and external collaborators.
• Develop and implement sample preparation and automation protocols, optimize mass spectrometer performance, and adapt novel technologies.
• Oversee data generation and analysis of large-scale proteomics datasets.
• Work closely with an interdisciplinary team to identify potential novel drug targets.
• Stay engaged with scientific literature to remain up-to-date with the latest developments and novel approaches.
• Be proactive and open-minded in contributing to the achievement of the company’s goals in a dynamic and fast-paced start-up environment.
• Characterize novel drug targets and their mechanisms of action.
• Contribute to laboratory general organization and maintenance, manage laboratory stocks and ordering.
• Ensure compliance with good laboratory practices including safety regulations, data management, data recording in electronic notebooks and archiving.

Kenntnisse

Mass spectrometry

High throughput screening

Proteomics

Data analysis

Python/R

UHPLC

Team collaboration

English communication

Ausbildung

PhD in Biochemistry/Biology/Chemical Biology

Bachelor's/Master in Biotechnology/Biochemistry/Molecular Biology

Tools

Orbitrap Astral

timsTOF

S-trap/SP3

DIA-NN/Spectronaut

Tecan/Biomek/OT-2 automation

Jobbeschreibung

The role requires hands-on experience with proteomics, UHPLC and high-resolution MS, and strong collaboration and communication skills in English. Joining the team offers a modern lab, commuter benefits, and opportunities for professional growth.