Senior Scientist, Biomarker Development

Proclinical; Basel; On-site; CHF 120,000 - 160,000; Full time

Job summary

Proclinical is seeking a Senior Scientist in Biomarker Development in Switzerland to lead the development and validation of cutting‑edge soluble biomarker assays. You will work hands‑on in the lab on ELISA, MSD, NULISA, Ella, and LC‑MS platforms, and collaborate with global teams to implement innovative biomarker technologies in clinical programs.

You will transfer and monitor assay development with external providers, generate data for proof of mechanism and biology readouts, and present

Qualifications

• Degree in Biology, Immunology, Cell Biology, or related field.
• Experience with ligand binding assays (ELISA, MSD, NULISA, Ella).
• Knowledge of regulatory requirements (GCLP, ICH) relevant to biomarker development.
• Strong written and verbal communication; collaborative team player.

Responsibilities

• Develop and validate soluble biomarker assays (ELISA, MSD, NULISA, Ella; LC‑MS).
• Transfer, implement, and monitor biomarker assay development at external providers.
• Generate and interpret biomarker data for PoC, dose selection, and biology readouts.
• Present results at internal reviews; ensure timely, high‑quality data delivery.
• Lead strategy and data interpretation for exploratory biomarker assays aligned with study endpoints.

Skills

Ligand binding assays

LC‑MS knowledge

Analytical thinking

Regulatory familiarity

Collaboration & communication

Education

Biology/Immunology/Cell Biology degree

Tools

Excel

Word

PowerPoint

SoftMax Pro

GraphPad Prism

Watson LIMS

Job description

Ready to shape the future of precision medicine by developing cutting-edge biomarker assays that accelerate smarter clinical decisions and improve patient outcomes?

Proclinical is seeking a Senior Scientist specializing in Biomarker Development to join a dynamic team in Switzerland. In this hands‑on, laboratory‑based role, you will focus on developing and validating state‑of‑the‑art biomarker assays to support clinical programs. Collaborating with global experts, you will contribute to the implementation of innovative biomarker technologies, enabling smarter decision‑making and improved patient outcomes.

Please note that to be considered for this role you must have the right to work in this location or hold an EU passport.

Responsibilities:

• Develop and validate soluble biomarker assays, with a focus on ligand binding assays such as ELISA, MSD, NULISA, and Ella, as well as advanced technologies like LC‑MS.


• Provide expertise in transferring, implementing, and monitoring biomarker assay development, validation, and sample analysis at external providers.


• Generate and interpret biomarker assay data to support proof of mechanism, dose selection, and proof of biology in early clinical programs.


• Present results at internal meetings and ensure the quality and timely delivery of data from both internal and outsourced activities.


• Serve as the scientific and technical lead for exploratory soluble biomarker assays, including strategy, data quality, interpretation, documentation, and alignment with clinical study endpoints.


• Maintain high standards for scientific rigor, data integrity, compliance, safety, and technical excellence.

Key Skills and Requirements:

• Degree in Biology, Immunology, Cell Biology, or a related field, with relevant laboratory experience.


• Strong expertise in ligand binding assays; experience with LC‑MS methods and related technologies is a plus.


• Analytical thinking, accountability, and collaborative teamwork skills.


• Familiarity with regulatory requirements relevant to biomarker development (e.g., GCLP, ICH).


• Proficiency in software tools such as Excel, Word, PowerPoint, SoftMax Pro, SMART Book, GraphPad Prism, and Watson LIMS.


• Strong written and verbal communication skills.


• Experience working in a global organization or matrix‑resourcing model is advantageous.


• Applicants must hold an EU/EFTA or Swiss passport or have an unrestricted Swiss residence/work permit.