Cellular Assay Development Research Associate

Roche; Basel; Vor Ort; CHF 120.000 - 170.000; Vollzeit

Zusammenfassung

Roche’s Pharmaceutical Research and Early Development (pRED) organization seeks a scientist to develop and optimize cell‑based assays, including 3D models, to power drug discovery. You will miniaturize workflows to 384‑ and 1536‑well formats and work with automated systems to deliver robust, high‑quality data.

You will maintain diverse mammalian cell lines, analyze complex datasets with Genedata Screener and Spotfire, and present findings to cross‑functional teams, contributing to SAR studies

Qualifikationen

• Master’s degree in Cell Biology, Molecular Biology, or a closely related scientific discipline.
• 5+ years of industry research experience focused on advanced cell culture and cell‑based assay development.
• Experience miniaturizing assay workflows into 384‑ and 1536‑well plate formats and utilizing automated liquid‑handling systems.
• Strong proficiency in data analysis, statistical evaluation, and presenting scientific findings clearly to multidisciplinary teams.
• Fluency in English with strong interpersonal and communication skills.
• Nice to have: iPSC differentiation, 3D cellular models, or Design‑of‑Experiments (DoE) methodology.

Aufgaben

• Developing, optimizing, and validating robust cell‑based functional assays—including complex 3D models—using technologies such as HTRF, AlphaLISA, Luminescence, and High‑Content Imaging
• Miniaturizing cellular assays into high‑density plate formats (384‑well and 1536‑well plates), optimizing performance parameters such as Z’‑factor and signal‑to-background ratio
• Maintaining, characterizing, and performing quality control on a wide range of mammalian cell lines, including primary cells, continuous lines, and induced pluripotent stem cells (iPSCs)
• Partnering closely with the High‑Throughput Screening and Profiling team to seamlessly transfer new assays onto integrated robotic systems
• Running routine cellular assays to generate high‑quality data supporting structure‑activity relationship (SAR) studies for portfolio projects
• Analyzing complex screening datasets using modern scientific tools (e.g., Genedata Screener, Spotfire) and documenting workflows meticulously in Electronic Lab Notebooks (ELN)
• Serving as the primary cellular assay expert on multidisciplinary project teams, sharing insights across chemistry, High‑Throughput Screening and Profiling, and therapeutic area groups

Kenntnisse

Cell culture

Cell-based assay development

384/1536‑well miniaturization

Automated liquid handling

Data analysis

Statistics

English communication

iPSC differentiation (nice to have)

3D cellular models (nice to have)

Ausbildung

Master’s degree in Cell Biology / Molecular Biology

Tools

Genedata Screener

Spotfire

Electronic Lab Notebook (ELN)

Jobbeschreibung

Roche’s Pharmaceutical Research and Early Development (pRED) organization seeks a scientist to develop and optimize cell‑based assays, including 3D models, to power drug discovery. You will miniaturize workflows to 384‑ and 1536‑well formats and work with automated systems to deliver robust, high‑quality data.

You will maintain diverse mammalian cell lines, analyze complex datasets with Genedata Screener and Spotfire, and present findings to cross‑functional teams, contributing to SAR studies