Scientist, Cell Engineering and Phenotypic Screening Models

F. Hoffmann-La Roche AG; Basel; Vor Ort; CHF 140.000 - 190.000; Vollzeit

Zusammenfassung

F. Hoffmann-La Roche AG in Basel seeks a scientist to design and optimize cellular models powering phenotypic screening and drug discovery. You will apply CRISPR/Cas, generate stable cell lines, and enable scalable workflows for high-content imaging.

PhD in cell biology or related field required; strong communication in English and collaboration across teams are essential. This is a 100% lab-based role in a leading pharmaceutical research setting.

Qualifikationen

• PhD in cell biology, molecular biology, or closely related discipline.
• Postdoctoral or industry research experience is a plus but not required.
• Strong hands-on experience with advanced cell culture and genome editing.

Aufgaben

• Design and optimize disease-relevant cellular models at scale for phenotypic screening.
• Apply CRISPR/Cas and other methods to build robust assay systems.
• Translate models into scalable workflows for high-content imaging and screening.
• Collaborate with automation, data analysis, and chemistry teams to drive decisions.
• Foster an inclusive, collaborative lab culture focused on scientific innovation.

Kenntnisse

CRISPR/Cas genome editing

Stable cell line generation

NGS genotyping

iPSC differentiation

Molecular cloning

Transfection / viral transduction

High-content imaging

Multiparametric data analysis

English communication

Ausbildung

PhD in cell biology or related field

Tools

NGS platforms

CRISPR design tools

Jobbeschreibung

## Scientist, Cell Engineering and Phenotypic Screening ModelsCandidatar-selocations: Baseltime type: Tempo integralposted on: Publicado hojejob requisition id: 202606-116615Na Roche, você pode-se apresentar como você mesmo, abraçado pelas qualidades únicas que traz. Nossa cultura incentiva a expressão pessoal, o diálogo aberto e as conexões genuínas, onde você é valorizado e respeitado por quem você é, e permitindo que você prospere tanto pessoal como profissionalmente. É assim que pretendemos prevenir, deter e curar doenças e garantir que todos tenham acesso aos cuidados de saúde hoje e nas gerações futuras. Junte-se à Roche, onde cada voz é importante.### A posiçãoIn Roche’s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world’s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility, and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed. Therapeutic Modalities (TMo) organization, accountable for translating disease biology into high-quality drug candidates across small molecules, large molecules, oligonucleotides, and genomic medicines. By integrating deep modality expertise with cross-disciplinary collaboration, TMo drives innovation within and across platforms to enable differentiated, sustainable therapeutic impact.## ### The OpportunityJoining Small Molecule Research Discovery within Therapeutic Modalities, you will work within a highly engaged, cross-functional team bridging cell biology, automation, and multiple therapeutic areas. In this role, you drive innovation through strong commitment to lab science by developing the foundational cellular models that power our drug discovery pipeline.Key responsibilities include:* Model Innovation: Independently design, engineer, validate, and optimize disease-relevant cellular models at scale to enable phenotypic screening and small molecule drug discovery.* Advanced Engineering: Apply diverse cell engineering approaches, including CRISPR/Cas technologies, vector design, reporter systems, and stable cell line generation, to build robust assay systems.* Pipeline Integration: Translate complex cellular models into scalable, reproducible, screening-compatible workflows for high-content imaging and phenotypic screening.* Cross-Functional Collaboration: Partner actively across therapeutic areas, automation, data analysis, and chemistry teams to interpret results, present data, and support project decisions.* Culture Contribution: Actively cultivate an inclusive, collaborative, and curious team environment focused on pushing scientific boundaries.## ### Who You AreYou are a curious, highly motivated scientist who thrives on solving complex biological challenges. You bring a collaborative mindset and are eager to apply your technical expertise to discover life-changing treatments.To thrive in this role, you bring:* **Education & Experience:** A PhD in cell biology, molecular biology, or a closely related scientific discipline. Postdoctoral or industry research experience is a plus but not required.* **Cell Culture Expertise:**Strong hands-on experience in advanced cell culture techniques, including iPSC differentiation and larger-scale cell culture.* **Advanced Genome Editing:**Extensive practical experience in cell engineering, particularly CRISPR/Cas-based genome editing, stable cell line generation, clonal isolation, genotyping, and validation using Next-Generation Sequencing (NGS).* **Molecular Biology Proficiency:** Solid experience with cloning, transfection, viral transduction, nucleofection, as well as plasmid, vector, and genetic element design (promoters, reporters, tags).* **Imaging & Screening:**Solid exposure to high-content imaging, assay development, automated cell culture, or high-throughput screening using small molecules or genetic tools. Expertise in high-content data analysis, image processing pipelines, or multiparametric data evaluation is a plus.* **Communication & Mindset**: Resourceful, flexible problem-solving skills with a highly collaborative approach and strong communication skills in English.****Please be advised that this position is 100% lab-based.******Ready to apply?** If you are excited about this opportunity, we would love to hear from you! Please submit your application through our portal, ensuring you include your updated CV or resume, a cover letter detailing your interest and fit for the role, and copies of your diplomas and any relevant certificates.