Senior Bio-Analytical Scientist (Midrand) - LC-MS/MS Expert

Placements24; Midrand; Hybrid; ZAR 1,100,000 - 1,600,000; Full time

Job summary

Placements24 is seeking a Senior Bio-Analytical Scientist in Midrand, Gauteng, SA, to lead bio-analytical method development and validation for small and large molecules. You will work on preclinical and clinical samples using LC-MS/MS, ELISA, and related assays, ensuring GLP-compliant data and precise reporting.

The role requires a Ph.D./MSc with 5+ years in the field, strong problem-solving, and ability to collaborate across teams in a fast-paced biotech environment.

Qualifications

• Ph.D. or Master’s in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related discipline.
• Minimum of 5 years in bio-analytical method development/validation within pharma/biotech.
• Expertise in LC-MS/MS; ELISA, HPLC, or HIC is a plus.
• Proficiency in GLP regulations (FDA, EMA).
• Strong problem-solving, attention to detail, and ability to work independently and collaboratively in a fast-paced environment.
• Proficiency in data analysis software (Watson LIMS, SoftMax Pro, Excel).

Responsibilities

• Develop, validate, and implement robust bio-analytical methods for small and large molecules (e.g., peptides, proteins, antibodies) using LC-MS/MS, ELISA, and Immunoassays.
• Analyze biological samples (plasma, serum, urine, tissues) from preclinical and clinical studies, ensuring accuracy and timely reporting.
• Troubleshoot and optimize existing bio-analytical assays to improve sensitivity, specificity, and efficiency.
• Maintain detailed lab notebooks, experimental records, and reports in compliance with GLP.
• Perform method transfer activities and provide technical support to CROs and internal teams.
• Characterize reference standards and contribute to PK/PD data analysis.
• Stay abreast of literature and regulatory guidelines relevant to bio-analysis.

Skills

LC-MS/MS expertise

GLP knowledge

Problem solving

Communication skills

Independent & collaborative work

Education

Ph.D. or Master’s in Analytical Chemistry/Pharmaceutical Sciences/Biochemistry

Tools

Watson LIMS

SoftMax Pro

Excel

Job description

Placements24 is seeking a Senior Bio-Analytical Scientist in Midrand, Gauteng, SA, to lead bio-analytical method development and validation for small and large molecules. You will work on preclinical and clinical samples using LC-MS/MS, ELISA, and related assays, ensuring GLP-compliant data and precise reporting.

The role requires a Ph.D./MSc with 5+ years in the field, strong problem-solving, and ability to collaborate across teams in a fast-paced biotech environment.