Principal Bioanalytical Scientist

Placements24; Gqeberha; On-site; ZAR 1,200,000 - 2,000,000; Full time

Job summary

Placements24 in Port Elizabeth, Eastern Cape, seeks a Principal Bioanalytical Scientist to lead development, validation, and application of sensitive LC-MS/MS bioanalytical methods across drug discovery and development programs.

You will oversee complex projects, ensure data integrity and GLP compliance, mentor junior scientists, and collaborate with DMPK and clinical teams to shape bioanalytical strategy and regulatory submissions.

Qualifications

• PhD required in analytical/biomedical field with relatedPhD.
• 8+ years hands-on quantitative bioanalysis, LC-MS/MS focus.
• GLP method development, validation, sample analysis.
• Lead complex bioanalytical projects end-to-end.
• Strong understanding of drug metabolism & pharmacokinetics.

Responsibilities

• Lead development and validation of bioanalytical methods in biological matrices.
• Perform quantitative LC-MS/MS analysis and data interpretation.
• Troubleshoot assay issues and ensure timely, high-quality results.
• Manage project timelines, resources, and budgets.
• Ensure GLP compliance and regulatory guideline adherence.
• Mentor junior scientists in method development and analysis.
• Collaborate with DMPK, preclinical and clinical teams.
• Contribute to department strategy and tech advancement.
• Prepare method validation and study reports for regulatory submissions.
• Maintain a safe, organized lab environment.

Skills

Leadership

Mentorship

Communication

Strategic thinking

Problem-solving

Education

PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field

Tools

Watson LIMS

Analyst

Xcalibur

Job description

About the Role

Our client, a globally renowned pharmaceutical research organization, is seeking a distinguished Principal Bioanalytical Scientist to join their state-of-the-art laboratory in Port Elizabeth, Eastern Cape . This senior role is instrumental in leading the development, validation, and application of sensitive bioanalytical methods to support drug discovery and development programs. You will be responsible for overseeing complex analytical projects, ensuring the highest standards of scientific rigor and data integrity. The ideal candidate will possess extensive expertise in quantitative bioanalysis, particularly using LC-MS/MS, and a deep understanding of drug metabolism and pharmacokinetics (DMPK). This is a career-defining opportunity to contribute to cutting-edge research within a dynamic and well-resourced team.

Key Responsibilities

• Lead the development and validation of robust bioanalytical methods for small molecules and/or biologics in biological matrices (plasma, urine, tissue).
• Perform quantitative analysis of study samples using LC-MS/MS, UPLC, and other relevant technologies.
• Interpret complex analytical data, troubleshoot assay issues, and ensure timely delivery of high-quality results.
• Manage bioanalytical project timelines, resources, and budgets effectively.
• Ensure all bioanalytical activities are conducted in compliance with Good Laboratory Practice (GLP) and relevant regulatory guidelines.
• Mentor and guide junior scientists in method development, validation, and sample analysis.
• Collaborate closely with DMPK, preclinical, and clinical teams to define bioanalytical needs and provide critical data.
• Contribute to the scientific strategy of the bioanalytical department and identify opportunities for technological advancement.
• Write comprehensive method validation reports, study reports, and contribute to regulatory submissions.
• Maintain a safe and organized laboratory environment.

Requirements

• PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field.
• Minimum of 8 years of hands-on experience in quantitative bioanalysis, with a strong focus on LC-MS/MS.
• Demonstrated expertise in method development, validation, and sample analysis according to GLP guidelines.
• Proven ability to manage complex bioanalytical projects from start to finish.
• Strong understanding of drug metabolism, pharmacokinetics, and biotransformation.
• Experience with various biological matrices and sample preparation techniques.
• Excellent data analysis and interpretation skills, with proficiency in relevant software (e.g., Watson LIMS, Analyst, Xcalibur).
• Strong leadership, mentorship, and communication skills.
• Ability to work independently and collaboratively in a fast-paced, team-oriented setting in Port Elizabeth, Eastern Cape .
• Experience with biologics bioanalysis is a plus.

Benefits

Our client offers an exceptionally competitive salary, a comprehensive benefits package including medical, dental, and vision insurance, generous paid time off, and a robust retirement plan. Opportunities for continuous professional development, including attending scientific conferences and specialized training, are actively encouraged. This role is situated in the scenic coastal city of Port Elizabeth, Eastern Cape , providing an attractive work environment. Join a leading organization at the forefront of pharmaceutical innovation.