Senior Bioanalytical Scientist, LC-MS/MS & DMPK Lead

Placements24; Gqeberha; On-site; ZAR 1,200,000 - 2,000,000; Full time

Job summary

Placements24 in Port Elizabeth, Eastern Cape, seeks a Principal Bioanalytical Scientist to lead development, validation, and application of sensitive LC-MS/MS bioanalytical methods across drug discovery and development programs.

You will oversee complex projects, ensure data integrity and GLP compliance, mentor junior scientists, and collaborate with DMPK and clinical teams to shape bioanalytical strategy and regulatory submissions.

Qualifications

• PhD required in analytical/biomedical field with relatedPhD.
• 8+ years hands-on quantitative bioanalysis, LC-MS/MS focus.
• GLP method development, validation, sample analysis.
• Lead complex bioanalytical projects end-to-end.
• Strong understanding of drug metabolism & pharmacokinetics.

Responsibilities

• Lead development and validation of bioanalytical methods in biological matrices.
• Perform quantitative LC-MS/MS analysis and data interpretation.
• Troubleshoot assay issues and ensure timely, high-quality results.
• Manage project timelines, resources, and budgets.
• Ensure GLP compliance and regulatory guideline adherence.
• Mentor junior scientists in method development and analysis.
• Collaborate with DMPK, preclinical and clinical teams.
• Contribute to department strategy and tech advancement.
• Prepare method validation and study reports for regulatory submissions.
• Maintain a safe, organized lab environment.

Skills

Leadership

Mentorship

Communication

Strategic thinking

Problem-solving

Education

PhD in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field

Tools

Watson LIMS

Analyst

Xcalibur

Job description

Placements24 in Port Elizabeth, Eastern Cape, seeks a Principal Bioanalytical Scientist to lead development, validation, and application of sensitive LC-MS/MS bioanalytical methods across drug discovery and development programs.

You will oversee complex projects, ensure data integrity and GLP compliance, mentor junior scientists, and collaborate with DMPK and clinical teams to shape bioanalytical strategy and regulatory submissions.