Senior Bio-Analytical Scientist

Placements24; Midrand; Hybrid; ZAR 1,100,000 - 1,600,000; Full time

Job summary

Placements24 is seeking a Senior Bio-Analytical Scientist in Midrand, Gauteng, SA, to lead bio-analytical method development and validation for small and large molecules. You will work on preclinical and clinical samples using LC-MS/MS, ELISA, and related assays, ensuring GLP-compliant data and precise reporting.

The role requires a Ph.D./MSc with 5+ years in the field, strong problem-solving, and ability to collaborate across teams in a fast-paced biotech environment.

Qualifications

• Ph.D. or Master’s in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or related discipline.
• Minimum of 5 years in bio-analytical method development/validation within pharma/biotech.
• Expertise in LC-MS/MS; ELISA, HPLC, or HIC is a plus.
• Proficiency in GLP regulations (FDA, EMA).
• Strong problem-solving, attention to detail, and ability to work independently and collaboratively in a fast-paced environment.
• Proficiency in data analysis software (Watson LIMS, SoftMax Pro, Excel).

Responsibilities

• Develop, validate, and implement robust bio-analytical methods for small and large molecules (e.g., peptides, proteins, antibodies) using LC-MS/MS, ELISA, and Immunoassays.
• Analyze biological samples (plasma, serum, urine, tissues) from preclinical and clinical studies, ensuring accuracy and timely reporting.
• Troubleshoot and optimize existing bio-analytical assays to improve sensitivity, specificity, and efficiency.
• Maintain detailed lab notebooks, experimental records, and reports in compliance with GLP.
• Perform method transfer activities and provide technical support to CROs and internal teams.
• Characterize reference standards and contribute to PK/PD data analysis.
• Stay abreast of literature and regulatory guidelines relevant to bio-analysis.

Skills

LC-MS/MS expertise

GLP knowledge

Problem solving

Communication skills

Independent & collaborative work

Education

Ph.D. or Master’s in Analytical Chemistry/Pharmaceutical Sciences/Biochemistry

Tools

Watson LIMS

SoftMax Pro

Excel

Job description

About the Role

Our client, a pioneering force in biotechnology and pharmaceutical research, is seeking a highly skilled and motivated Senior Bio-Analytical Scientist to join their dynamic team. This pivotal role is based in Midrand, Gauteng, ZA , a hub of innovation and scientific advancement. The successful candidate will contribute significantly to the development of novel therapeutic compounds, playing a crucial part in preclinical and clinical studies. This position offers an exciting opportunity to work on cutting-edge projects, collaborate with leading researchers, and make a tangible impact on global health. The ideal candidate possesses a strong theoretical understanding coupled with extensive practical experience in bio-analytical method development and validation.

Key Responsibilities

• Develop, validate, and implement robust bio-analytical methods for small molecules and large molecules (e.g., peptides, proteins, antibodies) using techniques such as LC-MS/MS, ELISA, and Immunoassays.
• Analyze biological samples (plasma, serum, urine, tissues) from preclinical and clinical studies, ensuring accuracy, precision, and timely reporting of results.
• Troubleshoot and optimize existing bio-analytical assays to improve sensitivity, specificity, and efficiency.
• Maintain detailed and accurate laboratory notebooks, experimental records, and reports in compliance with Good Laboratory Practice (GLP) standards.
• Perform method transfer activities and provide technical support to contract research organizations (CROs) and internal teams.
• Characterize reference standards and contribute to pharmacokinetic (PK) and pharmacodynamic (PD) data analysis.
• Stay abreast of the latest scientific literature, technologies, and regulatory guidelines relevant to bio-analysis.

Requirements

• Ph.D. or Master's degree in Analytical Chemistry, Pharmaceutical Sciences, Biochemistry, or a related discipline.
• Minimum of 5 years of relevant industry experience in bio-analytical method development and validation, preferably within a pharmaceutical or biotechnology setting.
• Demonstrated expertise in LC-MS/MS is essential; experience with other bio-analytical techniques (ELISA, hPLC, HIC) is a significant advantage.
• Proficiency in GLP regulations and guidelines (FDA, EMA).
• Strong understanding of drug discovery and development processes.
• Excellent problem-solving skills, attention to detail, and ability to work independently and collaboratively in a fast-paced environment.
• Proficiency in data analysis software (e.g., Watson LIMS, SoftMax Pro, Excel).
• Strong written and verbal communication skills.

Benefits

Our client offers a competitive salary package commensurate with experience and qualifications. In addition to a motivating remuneration, employees benefit from comprehensive health insurance, a generous retirement fund contribution, opportunities for professional development and continuous learning, and a stimulating work environment that fosters innovation and scientific excellence. This role is based in the vibrant city of Midrand, Gauteng, ZA , providing access to excellent amenities and a thriving scientific community. The company also offers potential for career advancement within its expanding research divisions.