Remote Principal Scientist - Cryo-EM & Structural Biology

Placements24; Klerksdorp; Hybrid; ZAR 1,800,000 - 3,200,000; Full time

Benefits offered by this job

Remote work allowance

Home office setup support

Health, dental and vision insurance

Equity or stock options

Flexible hours

Unlimited paid time off

Professional development and training

Access to cutting-edge computational工具

Job summary

Placements24 is seeking a Principal Scientist in Structural Biology with deep Cryo-EM expertise to join a remote research team. You will determine high‑resolution structures and provide insights to drug discovery in a fully remote context.

The role requires leading projects, mentoring staff, and publishing results while collaborating with cross‑functional teams in a highly flexible digital environment.

Qualifications

• PhD in Structural Biology or related field with extensive Cryo-EM experience.
• 7+ years postdoc/industry experience in structural biology and cryo-EM.
• Proven ability to lead projects and mentor junior staff.

Responsibilities

• Lead high‑resolution Cryo‑EM structure determination projects for drug targets.
• Optimize sample prep, grid freezing, and data collection strategies.
• Perform advanced image processing and 3D reconstruction.
• Interpret data to elucidate mechanisms and binding modes.
• Collaborate with chemists/biologists to guide lead optimization.
• Develop new Cryo‑EM workflows to improve throughput and resolution.
• Mentor junior scientists and present findings internally and at conferences.
• Contribute to strategic planning of structural biology within remote R&D.

Skills

Cryo-EM leadership

Remote collaboration

Analytical thinking

Mentoring

Scientific communication

Education

PhD in Structural Biology

Tools

RELION

cryoSPARC

ChimeraX

PyMOL

Job description

Placements24 is seeking a Principal Scientist in Structural Biology with deep Cryo-EM expertise to join a remote research team. You will determine high‑resolution structures and provide insights to drug discovery in a fully remote context.

The role requires leading projects, mentoring staff, and publishing results while collaborating with cross‑functional teams in a highly flexible digital environment.