VP, Immunology Therapeutics & TCR Innovation

Moderna Inc.; Cambridge (MA); Presencial; USD 272.000 - 490.000; Jornada completa

Ventajas ofrecidas por este puesto de trabajo

Competitive healthcare

Well-being programs

Paid time off and sabbatical options

Equity opportunities

Location-specific perks

Descripción de la vacante

Moderna is seeking a scientific leader to head Therapeutics Immunology and drive the immunology mRNA portfolio from discovery to preclinical development. The VP will build a TCR capability, guide autoimmune programs, and shape strategy across internal platforms and external collaborations.

The role demands a distinguished track record in T cell biology, leadership of multidisciplinary teams, and a strong history of translating science into medicines.

Formación

• PhD/MD/MD-PhD with deep T cell immunology training.
• 15+ years of relevant biotech/pharma experience after terminal degree, including 5+ years leading multidisciplinary teams.
• Internationally recognized expertise in human T cell biology and TCR biology.
• Record of advancing therapeutic programs from discovery to preclinical development; IND/early development experience.
• Ability to build or scale a discovery platform and convert capabilities into programs.
• Expertise in TCR discovery, repertoire analysis, and cross-reactivity assessment.
• Strong knowledge of therapeutic protein or receptor engineering, developability, and translational biomarkers.
• Experience in autoimmune or inflammatory disease research with human data/models.
• Track record of influential scientific contributions (publications/patents).
• Outstanding communication skills to align scientists, executives, and external partners.
• Comfort with ambiguity, urgency, accountability, and decisive decision-making.
• Risk-taking mindset with evidence-based experimentation and learning from setbacks.
• Enterprise-minded, low-ego collaborator who develops leaders and builds trust.

Responsabilidades

• Set and execute scientific strategy for the mRNA immunology pipeline, establishing clear priorities across autoimmune disease, TCR-based medicines, and immune-modulating therapeutics.
• Oversee internal TCR capabilities including TCR deconvolution and an end-to-end TCR discovery and engineering engine to generate therapeutic TCRs at scale.
• Lead the autoimmune research portfolio from concept ideation to target and disease hypothesis through lead generation, candidate selection, pharmacology, translational strategy, and preclinical development.
• Establish rigorous decision criteria for efficacy, selectivity, cross-reactivity, developability, manufacturability, and translational relevance across immune-mediated mRNA modalities.
• Translate insights from patient samples, single-cell and immune-repertoire data, human genetics, functional genomics, and disease models into therapeutic concepts.
• Partner with mRNA science, lipid nanoparticle delivery, protein engineering, structural biology, computational biology, and AI teams to design medicines that exploit Moderna's technology platform.
• Serve as a key scientific partner to Clinical Development. Shape mechanism-based development plans, biomarker and patient-selection strategies, clinical pharmacology hypotheses, proof-of-mechanism studies, and interpretation of emerging clinical data.
• Shape Moderna’s R&D strategy by representing therapeutics immunology priorities with enterprise portfolio decisions and engaging senior leadership.
• Lead Therapeutics Immunology organization through senior scientific leaders, recruiting, developing, and retaining a high-performing team.
• External collaborations with academic investigators, biotech/pharma, CROs, and technology providers to accelerate strategy.
• Maintain an active external scientific presence through publications, conferences, advisory relationships, and engagement with immunology leaders.
• Establish and manage the function's budget, headcount, technology investments, and portfolio commitments in alignment with Research priorities.

Conocimientos

PhD/MD/MD-PhD in immunology

15+ years in biotech/pharma

T cell immunology expert

Discipline leadership of teams

TCR discovery expertise

Protein/receptor engineering knowledge

Autoimmune/inflammatory disease work

Publications/patents track record

Strong communication skills

Decision making under uncertainty

Leadership & mentorship

External collaboration experience

Strategic portfolio shaping

Educación

Terminal degree in immunology or related field

Descripción del empleo

Moderna is seeking a scientific leader to head Therapeutics Immunology and drive the immunology mRNA portfolio from discovery to preclinical development. The VP will build a TCR capability, guide autoimmune programs, and shape strategy across internal platforms and external collaborations.

The role demands a distinguished track record in T cell biology, leadership of multidisciplinary teams, and a strong history of translating science into medicines.