VP, Immunology & TCR Therapeutics—mRNA Platform

Moderna; Cambridge (MA); On-site; USD 350,000 - 650,000; Full time

Job summary

Moderna is seeking a world-class scientific leader to head Therapeutics Immunology as VP, translating deep T cell biology into next-generation immunology programs. The role spans discovery to preclinical development, leveraging Moderna's mRNA, delivery, and computational platforms.

You will build a differentiated TCR capability, guide autoimmune and TCR-based programs, and partner with Clinical Development to drive mechanistic understanding and translational success.

Qualifications

• PhD, MD, or MD/PhD in immunology or related discipline with deep training in T cell immunology.
• At least 15 years of relevant biotech/pharma R&D experience after terminal degree, including 5+ years leading multidisciplinary teams.
• Internationally recognized expertise in human T cell biology, including TCR peptide-MHC biology and immune tolerance.

Responsibilities

• Set and execute the scientific strategy for the mRNA therapeutics immunology pipeline across autoimmune disease and TCR-based medicines.
• Oversee internal TCR capabilities and end-to-end TCR discovery and engineering at scale.
• Lead autoimmune research portfolio from concept through lead generation, candidate selection, pharmacology, translational strategy, and preclinical development.
• Establish rigorous decision criteria for efficacy, developability, and translational relevance across immune-mediated modalities.
• Translate patient data, single-cell and immune-repertoire data into therapeutic concepts.
• Collaborate with mRNA science, delivery, protein engineering, and AI teams to design differentiated medicines.
• Partner with Clinical Development to shape mechanism-based development plans and biomarker strategies.
• Represent Therapeutics Immunology in senior forums and steer portfolio and resource decisions.
• Lead & develop a high-performing team, maintain scientific rigor, and foster external collaborations with academia, biotech, and CROs.

Skills

Deep T cell immunology

Drug-discovery leadership

Portfolio strategy

Cross-functional leadership

External collaborations

Education

PhD/MD/MD-PhD in immunology

Job description

Moderna is seeking a world-class scientific leader to head Therapeutics Immunology as VP, translating deep T cell biology into next-generation immunology programs. The role spans discovery to preclinical development, leveraging Moderna's mRNA, delivery, and computational platforms.

You will build a differentiated TCR capability, guide autoimmune and TCR-based programs, and partner with Clinical Development to drive mechanistic understanding and translational success.