Senior Scientist, Translational Bioinformatics for mRNA

Moderna Therapeutics; Cambridge (MA); On-site; USD 146,000 - 234,000; Full time

Benefits offered by this job

Healthcare coverage

Well-being programs

Paid time off

Location-specific perks

Job summary

Moderna Therapeutics is seeking a Senior Scientist in Therapeutics & Translational Bioinformatics to drive computational analyses for mRNA-based therapeutics and vaccines. You will lead multi-omics and single-cell analyses, integrating TCR/BCR repertoire data to uncover biomarkers and patient stratification factors.

The role demands a PhD in a quantitative field with 2+ years of postdoctoral or industry experience, strong programming in R/Python, and expertise in cloud computing and AI-driven

Qualifications

• PhD in Computational Immunology, Bioinformatics, Biomedical Engineering, or related quantitative field; 2+ years postdoc/industry experience.
• Strong foundation in computational biology and immunology; connect molecular findings to immune mechanisms.
• Experience applying computational analyses to human, preclinical, and in vitro data for therapeutic development.
• Experience with immune-mediated diseases, oncology, infectious diseases, or mRNA therapeutics/vaccines.
• Strong skills in processing and interpreting bulk and single-cell transcriptomics; multi-omics integration.
• Experience with machine-learning or advanced statistical models in biological datasets.
• Strong programming in R and/or Python; comfortable in Linux; use of AI-enabled tools for pipelines.
• Experience with cloud-based computing and platforms (AWS, GitHub/GitLab, Jupyter, Docker, Nextflow).
• Proven ability to lead complex computational projects and collaborate across teams.

Responsibilities

• Lead computational efforts for therapeutic programs with cross-functional teams.
• Perform integrated multi-omics analyses across clinical, translational, and preclinical data.
• Conduct bulk and single-cell transcriptomic analyses with QC and annotation.
• Analyze TCR/BCR repertoires and relate clonotypes to phenotypes.
• Develop or apply ML/DL approaches for biomarker discovery and patient stratification.
• Integrate immune-assay data (flow, cytokines, serology, ELISpot) with analyses.
• Translate findings into testable hypotheses and actionable recommendations.
• Develop scalable, well-documented analytical pipelines using data science best practices.
• Communicate findings through presentations and regulatory/clinical docs.
• Provide technical leadership and mentorship to junior scientists.

Skills

Computational biology

Immunology

Machine learning

Single-cell transcriptomics

TCR/BCR repertoire

Multi-omics integration

R/Python

Linux

Cloud computing

Education

PhD in Computational Immunology

Tools

Docker

Nextflow

GitHub

AWS

Job description

Moderna Therapeutics is seeking a Senior Scientist in Therapeutics & Translational Bioinformatics to drive computational analyses for mRNA-based therapeutics and vaccines. You will lead multi-omics and single-cell analyses, integrating TCR/BCR repertoire data to uncover biomarkers and patient stratification factors.

The role demands a PhD in a quantitative field with 2+ years of postdoctoral or industry experience, strong programming in R/Python, and expertise in cloud computing and AI-driven