Upstream LVV Scientist (CAR-T Process & Scale-Up)

Insight Global; Spring House (PA); On-site; USD 48,000 - 76,000; Full time

Benefits offered by this job

Medical insurance

Dental insurance

Vision insurance

HSA

FSA

DCFSA

401k matching

Paid time off

Job summary

Insight Global is assisting a large pharmaceutical client in Spring House, PA to hire an Upstream Associate Scientist focused on LVV production for CAR T manufacturing. The role requires performing cell culture, operating 10–50 L bioreactors, and driving scale-down studies.

You will collect data, generate technical reports, and support process transfer while ensuring safety, quality, and regulatory standards. Collaboration with internal and external teams is essential.

Qualifications

• Bachelor’s or Master’s degree in a relevant scientific discipline with 3–5 years of lab-based experience.
• Experience with aseptic cell culture and routine analysis of pH, gases, metabolites, cell densities, and viabilities.
• Experience with large-scale bioreactors (wave or stirred-tank, single-use preferred).
• Strong analytical and troubleshooting skills with data-driven mindset.
• MS Office proficiency for data aggregation and analysis.

Responsibilities

• Execute routine suspension cell culture and aseptic preculture operations, including cell vial thawing, shake flask expansion, wave bag preparation, and bioreactor setup.
• Perform LVV production runs at scales ranging from 10 L to 50 L using single-use bioreactors with focus on sterility and process consistency.
• Conduct Ambr and shake flask scale-down studies to support platform development and material generation.
• Management of experimental samples, including aliquoting, storage, and shipment as needed.
• Collect and analyze post-run data, generate technical reports, and present findings to cross-functional teams.
• Maintain accurate records of analytical data and ensure compliance with safety, quality, and regulatory standards.
• Collaborate with internal and external stakeholders to support onboarding of new processes and resolution of technical challenges.
• Contribute to ongoing improvements in the existing CAR T process and support development of new LVV platforms.

Skills

Upstream cell culture

LVV production

Data analysis

Microsoft Office

Education

Bachelor’s or Master’s degree

Tools

Bioreactors

Ambr

Shake flasks

pH/gases/metabolites

Job description

Insight Global is assisting a large pharmaceutical client in Spring House, PA to hire an Upstream Associate Scientist focused on LVV production for CAR T manufacturing. The role requires performing cell culture, operating 10–50 L bioreactors, and driving scale-down studies.

You will collect data, generate technical reports, and support process transfer while ensuring safety, quality, and regulatory standards. Collaboration with internal and external teams is essential.