Principal LVV Upstream Scientist, CAR‑T Platform

Merck & Co.; Philadelphia (Philadelphia County); On-site; USD 146,000 - 192,000; Full time

Benefits offered by this job

Medical, dental, vision

401(k) plan

Parental leave

Job summary

Legend Biotech in Philadelphia seeks a Principal Scientist to lead early LVV process development for in‑vivo CAR‑T programs. You will define seed‑train strategies from shake flask to bench scale, establish foundational process parameters, and build a scalable LVV platform with a robust developable base for late‑stage work.

The role blends molecular biology depth with bioprocess engineering breadth, requiring hands‑on viral vector production, DoE, analytics collaboration, and cross‑functional

Qualifications

• Advanced degree with molecular biology/virology foundation preferred.
• Hands-on viral vector production and upstream process development experience.
• Experience translating early processes to manufacturable platforms.
• Strong DoE, data interpretation, and risk-based decision skills.

Responsibilities

• Lead early LVV seed-train and upstream development strategies.
• Collaborate cross-functionally to ensure process coherence from construct to transfer.
• Prepare data packages and stage-gate deliverables for IND timelines.

Skills

Viral vector production

Upstream bioprocessing

Mammalian cell culture

DoE/experimental design

IND-enabling timelines

Education

MS/PhD in Bioengineering or related

Tools

Chromatography

Tangential flow filtration

Bioreactor operations

Job description

Legend Biotech in Philadelphia seeks a Principal Scientist to lead early LVV process development for in‑vivo CAR‑T programs. You will define seed‑train strategies from shake flask to bench scale, establish foundational process parameters, and build a scalable LVV platform with a robust developable base for late‑stage work.

The role blends molecular biology depth with bioprocess engineering breadth, requiring hands‑on viral vector production, DoE, analytics collaboration, and cross‑functional