Translational Medicine Lead, Early Clinical Development

Madrigal Pharmaceuticals; Conshohocken (Montgomery County); Hybrid; USD 259,000 - 317,000; Full time

Benefits offered by this job

Equity

Bonus potential

Comprehensive benefits package

401(k) offerings

Job summary

Madrigal Pharmaceuticals is seeking a Senior Medical Director, Translational Medicine & Early Clinical Development to lead early development and mechanistic studies. You will integrate clinical, biomarker, and mechanistic data to inform go/no-go decisions and lifecycle management.

You will chair translational teams and partner across Research, Clinical Development, and Regulatory. This role requires MD with extensive clinical development experience, leadership of interventional early trials, and

Qualifications

• MD with 15+ years in clinical development and leadership of early phase interventional trials.
• Strong track record in translational medicine and biomarker-driven development.
• Experience interacting with regulatory agencies on early development and biomarker topics.
• Demonstrated ability to lead cross-functional teams and influence stakeholders.
• Excellent communication skills to articulate complex mechanistic concepts.

Responsibilities

• Serve as global medical lead / medical monitor for early phase studies (FIH, PoC, mechanistic, indication-expansion).
• Design study concepts and protocols including populations, endpoints, and mechanistic sub-studies.
• Provide ongoing medical oversight: eligibility, safety, dose decisions, data interpretation.
• Partner with Clinical Operations and CROs for high-quality execution and inspection-readiness.
• Chair or co-chair early asset teams and interface with Research, Clinical Development, Regulatory.

Education

MD with clinical training in hepatology / gastroenterology / endocrinology / cardiology / internal medicine

Job description

Madrigal Pharmaceuticals is seeking a Senior Medical Director, Translational Medicine & Early Clinical Development to lead early development and mechanistic studies. You will integrate clinical, biomarker, and mechanistic data to inform go/no-go decisions and lifecycle management.

You will chair translational teams and partner across Research, Clinical Development, and Regulatory. This role requires MD with extensive clinical development experience, leadership of interventional early trials, and