Technical Project Manager II - eCOA

Y-Prime, LLC; Malvern (Chester County); On-site; USD 110,000 - 150,000; Full time

Job summary

YPrime, LLC is seeking a Technical Project Manager II - eCOA in Malvern, PA. This role leads complex technology projects from initiation to completion, ensuring alignment with business goals and stakeholder expectations while managing risk and budget.

Strong cross-functional collaboration, communication, and problem-solving are essential for success. You will translate technical requirements into actionable plans, oversee SDLC adherence, and help drive continuous process improvements across the

Qualifications

• Bachelor's degree in a related field or equivalent experience preferred.
• Proficient with MS Office and basic SQL queries.
• Foundational knowledge of SDLC; SaaS delivery experience is a plus.
• Biotech/pharma or CRO industry experience preferred.

Responsibilities

• Lead and oversee complex technology projects from initiation through completion.
• Coordinate resources and maintain clear communication with stakeholders.
• Translate requirements into actionable project plans and manage risk and issues.
• Ensure projects stay on time and within budget; align with SDLC processes.
• Mentor junior team members and support cross-functional collaboration.

Skills

eCOA experience

Communication skills

Attention to detail

Time management

Problem solving

Ownership / proactivity

Education

Bachelor's degree or equivalent experience

MS Office proficiency

SQL Server knowledge

Tools

SQL Server

Job description

If you are unable to complete this application due to a disability, contact this employer to ask for an accommodation or an alternative application process.

Technical Project Manager II - eCOA

eCOA Delivery Full Time Malvern, PA, US

2 days ago Requisition ID: 1046

About YPrime:

At YPrime, we pioneer solutions that streamline the clinical trial journey, increasing certainty from study design to data lock. With a foundation built on decades of industry insight and expertise, we are inspired by the life‑altering outcomes unlocked by clinical trials. Our dedication to quality is pivotal in propelling the groundbreaking endeavors of our partners, researchers, and investigators. With a technology platform that enables speed, flexibility, and certainty for large and emerging pharma companies alike, we provide eConsent, eCOA, IRT, and patient engagement solutions that solve with certainty in clinical research.

About the Role:

The Technical Project Manager eCOA will lead and oversee complex technology projects from initiation through completion, ensuring alignment with organizational goals and stakeholder expectations. This role requires working well with cross‑functional teams, coordinating resources, and maintaining clear communication channels to deliver projects on time and within budget. The successful candidate will translate technical requirements into actionable project plans, balancing technical constraints with business needs. They will be responsible for risk management, issue resolution, and continuous process improvement throughout the project life cycle. Ultimately, this position drives the successful delivery of innovative information systems solutions that enhance operational efficiency and support strategic objectives.

Responsibilities:

• Ensure all requirements for system build are identified, documented, and communicated across the project team
• Consistent implementation of Software Development Life Cycle (SDLC)
• Responsible for the technical design of basic studies based on protocol, client requests and experience
• Review and support configuration of basic systems; understand the capabilities of base product to ensure custom code is not created inadvertently
• Ensures all functional requirements are captured in Systems Requirements Document (SRD) and other applicable system requirements documents
• Group functionalities and requirements that are similar together, and approach the design holistically
• Translates functional requirements into technical specifications for programmers
• Leads team in ad‑hoc testing of requirements in development environment
• Ensures delivery of a clean study through validation environment
• Objectively review and approve system documentation and specifications as required
• Ensure documentation completeness and compliance of all YPrime SOPs and WIs
• Support system validation through the timely triaging of defects
• Demonstrates software prototypes for customers
• Assist in mentoring configuration specialists, if applicable
• Sets and tracks project milestones related to technical delivery; manages and accounts for unforeseen delays, then realigns schedules and expectations as needed.
• Communicates and coordinates project milestones with internal team
• Assist in mentoring more junior Technical Project Managers
• Assist in project scoping and change control processes, including revision management
• Adopts new processes and skills with minimal to no managerial oversight
• Responsible for the technical design of intermediate studies and system changes based on protocol, client requests and experience
• Review and support configuration of intermediate systems
• Research defect record frequency by type and proposes methods to reduce defect records, if applicable
• Works independently with YPrime team members to rectify UAT issues
• Work with cross‑functional groups at YPrime to help develop, implement and document standards
• Uses past experiences and advanced knowledge of the system to strategically plan and mitigate risk
• Support audit preparation and activities as expected
• Perform other related duties as required

Skills:

• Comfort working with eCOA required
• Excellent verbal and written communication skills
• Exceptional focus on detail
• Time management and organizational skills
• Creative problem‑solving ability
• Sense of ownership and proactivity

Education & Experience:

• Bachelor's degree in a related field or equivalent experience, preferred
• Proficient in MS Office applications required, database querying experience preferred (SQL Server)
• Foundational knowledge of the principles of SDLC required
• Experience in biotech/pharmaceutical or the CRO industry preferred
• Experience with Scrum Software Development is considered a plus
• Experience with SaaS delivery is considered a plus
• Experience with software systems in support of clinical trials