TCR-T Discovery Scientist II

Weill Cornell Medicine; New York (NY); On-site; USD 140,000 - 190,000; Full time

Job summary

Weill Cornell Medicine in New York is seeking a Scientist, TCR-T, to drive development of personalized TCR-based cell therapies for autologous tumors. You will build high‑throughput discovery and preclinical platforms to identify tumor‑specific TCRs for downstream analysis and translation to clinical use.

The role requires a PhD in Immunology and 5+ years in human T cell immunology with TCR characterization.

Qualifications

• PhD in Immunology or related field is required.
• Minimum 5+ years post‑PhD experience in academia or industry.
• Prior 5+ years in human T cell immunology, TCR characterization and human T cell assays.

Responsibilities

• Contribute hands‑on to end‑to‑end personalized TCR discovery incl. tumor‑reactive T cell identification, TCR cloning & characterization, specificity validation, and safety de‑risking leading to selection of personalized TCRs for clinical application.
• Utilize advanced de‑risking methods and workflows to assess alloreactivity, unintended HLA interactions, off‑target toxicity risk including X‑scan, peptide library screens and library‑on‑library HTS.
• Analyze and interpret complex campaigns for identification of TCRs against known tumor antigens.
• Generate complete data packages across functional potency, specificity, and safety to support go/no‑go decisions on specific TCRs, their cloning, specificity validation, and safety de‑risking
• Support the design and execution of preclinical IND enabling studies. Generate and assemble data packages to enable decision making and TCR candidate selection for clinical application.
• Directly perform data analysis, prepare reports, maintain detailed and accurate records of experiments.
• Collaborate cross‑functionally with vector development, T cell translation, and other teams to integrate learnings and advance gene therapy initiatives.
• Operate with highest integrity and ethics, conduct all experiments following lab, department, and college policies and procedures.
• Mentor and train junior scientists and staff, promote scientific rigor, collaboration, independent thinking, and career advancement.
• Prepare scientific abstracts and articles, publish results in research journals, and present findings at conferences.

Skills

TCR biology

T cell immunology

Data analysis

Team collaboration

Education

PhD in Immunology

Tools

TCR cloning

HTS assays

Flow cytometry

Job description

Weill Cornell Medicine in New York is seeking a Scientist, TCR-T, to drive development of personalized TCR-based cell therapies for autologous tumors. You will build high‑throughput discovery and preclinical platforms to identify tumor‑specific TCRs for downstream analysis and translation to clinical use.

The role requires a PhD in Immunology and 5+ years in human T cell immunology with TCR characterization.