TCR-T Cell Engineering & Translation Lead (Assistant)

Weill Cornell Medicine; New York (NY); On-site; USD 129,000 - 146,000; Full time

Job summary

Weill Cornell Medicine seeks an Assistant Lead for TCR-T-cell Engineering and Translation to steer the development of next‑generation TCR‑engineered T‑cell therapies from concept to first‑in‑human studies.

The role drives scientific leadership across a multidisciplinary team, advancing projects through preclinical validation while ensuring regulatory readiness and rigorous data integrity.

Qualifications

• PhD required in immunology, molecular biology, cell biology or related field.
• 10+ years in translational immunology or cell/gene therapy.
• Experience in T cell engineering and therapeutics research.
• Proven ability to lead multidisciplinary scientific teams.

Responsibilities

• Lead a multidisciplinary research subteam and drive innovation and translation of discoveries.
• Develop cutting-edge approaches for precision TCR-T cell engineering for potent, durable products.
• Design and execute in vitro and in vivo studies to test TCR-T cell candidates.
• Guide vector architecture decisions for TCR-T strategies (promoters, payloads, safety switches).
• Define preclinical strategy with regulatory expectations and risk assessment.
• Mentor junior scientists, promote rigor, and foster collaboration.

Skills

Leadership

Translational immunology

TCR-T engineering

Cell therapy

Education

PhD in Immunology, Molecular Biology, Cell Biology or related field

Job description

Weill Cornell Medicine seeks an Assistant Lead for TCR-T-cell Engineering and Translation to steer the development of next‑generation TCR‑engineered T‑cell therapies from concept to first‑in‑human studies.

The role drives scientific leadership across a multidisciplinary team, advancing projects through preclinical validation while ensuring regulatory readiness and rigorous data integrity.