Scientist I, TCR-T Engineering and Translation

Weill Cornell Medicine; New York (NY); On-site; USD 70,000 - 83,000; Full time

Job summary

Weill Cornell Medicine's MCC Laboratories in New York seeks a Scientist I in TCR-T Engineering and Translation to support the development of IND-ready TCR-T cell candidates for clinical use.

Responsibilities include generating engineered TCR-T cells, performing functional assays, analyzing data, and collaborating across teams to advance projects. A Bachelor's degree and 8+ years of relevant experience are required.

Qualifications

• Bachelor's degree in biology or related field.
• 8+ years of research experience in academic, biotech or pharma settings.
• Experience manipulating and culturing human T cells and TCR-T engineering.

Responsibilities

• Support IND enabling preclinical studies for TCR-T programs.
• Generate engineered TCR-transduced T cells using molecular/genomic tech.
• Perform cell-based function assays to assess biological properties in vitro.
• Assess potency of TCR-T cells in tumor models in vivo.
• Analyze data, prepare summaries, and present findings at meetings.
• Maintain detailed lab records and write SOPs.
• Train researchers and staff in equipment and techniques as needed.
• Follow policies and collaborate with cross-functional teams.
• Stay current with literature and contribute to posters/manuscripts.

Skills

Collaborative

Multitask

Organizational skills

Excellent communication

Education

Bachelor's Degree in Biology, Biochemistry or related field

Job description

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Title: Scientist I, TCR-T Engineering and Translation

Title: Scientist I, TCR-T Engineering and Translation

Org Unit: MCC Laboratories

Work Days:

Weekly Hours:35.00

Exemption Status:Exempt

Salary Range:$70,200.00-$83,200.00

*As required under NYC Human Rights Law Int 1208-2018 - Salary range for this role when Hired for NYC Offices

Position Summary

Supports the development of next-generation T cell receptor (TCR)-engineered T cell therapies by preparing engineered TCR-T cells and testing their biological properties. This role reports to the Assistant Lead and works collaboratively with the broader team to deliver IND ready candidates for the clinic.

Job Responsibilities

• Support IND enabling preclinical studies for TCR-T cell programs.
• Generate engineered TCR-transduced T cells using molecular and genomic technologies/platforms.
• Perform cell-based function assays examining biological properties in vitro
• Assist in testing potency of TCR-T cells in tumor models in vivo.
• Analyze experimental data, prepare summaries, and present findings at team meetings.
• Maintain accurate and detailed record keeping of experimental methods and results in laboratory notebooks, write SOPs.
• As needed, assist in training researchers and laboratory staff in equipment use and experimental techniques.
• Operate with highest integrity and ethics, conduct all experiments following lab, department, and college policies and procedures.
• Collaborate cross-functionally with teams including TCR discovery and vector development.
• Stay current with literature and emerging technologies in the field. Contribute to writing of scientific posters and/or manuscripts.
• Perform other related duties as assigned.

Education

• Bachelor's Degree in Biology, Biochemistry or related field

Experience

• Minimum 8+ years research experience in an academic laboratory or in the biotechnology or pharmaceutical industry.
• Prior experience in manipulating and culturing human T cells, T cell engineering, molecular and cell biology techniques, conduct and analysis methods in adoptive T cell therapy using mouse tumor models.

Knowledge, Skills and Abilities

• Highly collaborative, ability to multitask and work cross-functionally.
• Strong organizational skills with the ability to pay close attention to detail.
• Excellent written and verbal communication skills.

Licenses and Certifications

Working Conditions/Physical Demands

Standard laboratory conditions; This position may require standing or sitting for long periods of time; This role may require working within Biologic Safety Level 1 and 2.

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